首页> 中国专利> 用于治疗患有恶性血液病的患者的方法

用于治疗患有恶性血液病的患者的方法

页面导航

摘要
著录项
法律信息
相似文献

摘要

本公开包括一种用于施用2,3‑二氢‑异吲哚‑1‑酮化合物或其药学上可接受的盐、酯、溶剂合物和/或前药以治疗血液癌症诸如急性骨髓性白血病(AML)的方法。本公开进一步涉及降低或抑制由野生型或突变Fms样酪氨酸激酶‑3受体(FLT3)活化的细胞增殖。本公开进一步涉及一种抑制或降低有需要的受试者中的异常(例如过度表达)野生型或突变BTK活性或表达的方法。

著录项

公开/公告号CN110621665A

专利类型发明专利
公开/公告日2019-12-27

原文格式PDF
申请/专利权人艾普托斯生物科学公司;晶体基因技术株式会社;
展开▼

申请/专利号CN201880018924.0
发明设计人 W·G·莱斯;J·M·曹;Y·洪;
展开▼

申请日2018-02-21
分类号
代理机构北京坤瑞律师事务所;
代理人封新琴
地址加拿大安大略省多伦多市
入库时间 2024-02-19 16:11:28

法律信息

法律状态公告日

法律状态信息

法律状态
2020-03-17

实质审查的生效 IPC(主分类):C07D403/10 申请日:20180221

实质审查的生效
2019-12-27

公开

公开

相似文献

专利
中文文献
外文文献

1. 用于治疗患有恶性血液病的患者的方法 [P] . 中国专利： CN110621665A . 2019-12-27
2. 患有轻度认知障碍需要治疗的患者的鉴定方法以及这种患者的治疗 [P] . 中国专利： CN101977594A . 2011-02-16
3. methods to inhibit b cell tumor cell proliferation, to treat a patient having a tumor, to treat a patient having a deregulated taki signaling transduction molecule, to inhibit the growth of a solid tumor, to select a patient having a tumor THAT IS SUSTAINABLE to treatment with a taki inhibitor, to inhibit the proliferation of a cell leukemia and t-cell lymphomas, and to select a mammal having or methods to inhibit the proliferation of b cell tumor cell, to treat a patient having a tumor, to treat a patient having a deregulated tak1 signaling transduction molecule, to inhibit the growth of a solid tumor, to select a patient having a tumor that is susceptible to treatment with a tak1 inhibitor, to inhibit the proliferation of a cell leukemia and t-cell lymphomas, and to select a mammal having or suspected of having a tumor for treatment with a medi inhibitor tak1 [P] . BRPI0714158A2 . 2012-12-25

机译：抑制b细胞肿瘤细胞增殖，治疗患有肿瘤的患者，治疗患有taki信号转导分子失调的患者，抑制实体瘤生长，选择具有治疗可持续性的肿瘤的方法使用taki抑制剂来抑制细胞白血病和t细胞淋巴瘤的增殖，并选择具有抑制b细胞肿瘤细胞增殖的哺乳动物或方法，以治疗患有肿瘤的患者，以治疗患有t细胞淋巴瘤的患者失调的tak1信号转导分子，以抑制实体瘤的生长，选择患有对tak1抑制剂治疗敏感的肿瘤的患者，以抑制细胞白血病和t细胞淋巴瘤的增殖，并选择患有或怀疑患有肿瘤的哺乳动物可使用tak1抑制剂治疗
4. phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs, compound, pharmaceutical composition, method for increasing cognition in a patient in whom such an increase is desired, method of treating a patient suffering from degeneration or decline in cognition, method for the treatment of a patient who has a disease involving reduced levels of camp, method of inhibiting the activity of the enzyme pde4 in a patient, method of treatment of a patient suffering from memory degeneration due to a neurodegenerative disease, method of treatment of a patient suffering from memory degeneration due to an acute neurodegenerative disorder, method of treating a patient suffering from an allergic or inflammatory disease, method of treating a patient suffering from schizophrenia, method of treating a patient who suffers from psychosis characterized by high levels of pd4, and said psychosis is a form of depression depression [P] . BRPI0417110A . 2007-02-06

机译：磷酸二酯酶4抑制剂，包括n-取代的二芳基胺类似物，化合物，药物组合物，在需要增加认知水平的患者中提高认知的方法，治疗患有认知能力下降或认知下降的患者的方法，患有与营地水平降低有关的疾病的患者，抑制患者体内pde4酶活性的方法，由于神经退行性疾病而患有记忆退化的患者的治疗方法，患有记忆退化的患者的治疗方法由于急性神经退行性疾病，治疗变态反应性或炎性疾病的患者的方法，治疗精神分裂症的患者的方法，治疗以pd4高水平为特征的精神病的患者的方法，并且所述精神病是抑郁症的形式
5. compound, pharmaceutical composition, method of selective activation/stimulation of nicotinic receptors from to-7 in a patient in which such activation/stimulation has a therapeutic effect, method of treating a patient suffering from a psychotic disease, a neurodegenerative disease involving a dysfunction of the cholinergic system, and/or a condition of impaired memory and/or cognition, method of treatment of a patient suffering from dementia and/or another condition with memory loss, method of treatment of a patient suffering from memory impairment due to mild cognitive impairment due to aging, alzheimer's malady,schizophrenia, parkinson malady, huntington malady, pick malady, creutzfeldt-jakob malady, depression, aging, head trauma, stroke, snc hypoxia, cerebral senility, multiinfarction dementia, HIV and/or cardiovascular disease, method of treatment and/or prevention of dementia in a patient with alzheimer's disease, method of treating a patient to cut off the alcohol vein or treat [P] . BRPI0517494A . 2008-10-14

机译：化合物，药物组合物，在其中这种激活/刺激具有治疗作用的患者中选择性激活/刺激烟碱受体从to-7的方法，治疗患有精神病，涉及神经功能障碍的神经退行性疾病的患者的方法胆碱能系统和/或记忆力和/或认知障碍的状况，患有痴呆症的患者的治疗方法和/或患有记忆力丧失的另一种状况，由于轻度认知障碍而遭受记忆力障碍的患者的治疗方法由于衰老，阿尔茨海默氏病，精神分裂症，帕金森氏病，亨廷顿氏病，匹克病，creutzfeldt-jakob病，抑郁症，衰老，头部外伤，中风，snc缺氧，脑衰老，多发性梗塞性痴呆，HIV和/或心血管疾病，治疗方法治疗和/或预防老年痴呆症患者的痴呆症，治疗患者的方法以切断酒精静脉或治疗