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岩白菜素在制备治疗体内肺炎克雷伯氏菌感染药物中的用途

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摘要

本发明提供了一种岩白菜素在在制备治疗体内肺炎克雷伯氏菌药物中的用途，属于生物及医药技术领域。本发明证明了岩白菜素可以通过改善肺炎克雷伯氏菌感染所引起的细胞生存率下降，改善肺炎克雷伯氏菌感染所引起的细胞氧化损伤，改善肺炎克雷伯氏菌感染所引起的炎症反应，改善肺炎克雷伯氏菌感染所引起的肺部损伤，降低肺部的肺炎克雷伯氏菌感染，抑制ERK，JNK，p38磷酸化以及抑制IκB和p65磷酸化来治疗肺炎克雷伯氏菌感染，本发明有助于岩白菜素的进一步开发利用。

著录项

公开/公告号CN110870862A

专利类型发明专利
公开/公告日2020-03-10

原文格式PDF
申请/专利权人中国农业大学;青岛农业大学;
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申请/专利号CN201911243711.0
发明设计人郝智慧;候冉冉;李秋;孙卓建;王苹苹;
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申请日2019-12-06
分类号
代理机构济南智圆行方专利代理事务所(普通合伙企业);
代理人梁轶聪
地址 100193 北京市海淀区圆明园西路2号
入库时间 2023-12-17 06:30:06

法律信息

法律状态公告日

法律状态信息

法律状态
2020-04-03

实质审查的生效 IPC(主分类):A61K31/37 申请日:20191206

实质审查的生效
2020-03-10

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公开

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1. 岩白菜素在制备治疗体内肺炎克雷伯氏菌感染药物中的用途 [P] . 中国专利： CN110870862B . 2021.11.05
2. 岩白菜素在制备治疗体内肺炎克雷伯氏菌感染药物中的用途 [P] . 中国专利： CN110870862A . 2020-03-10
3. composition, pharmaceutical composition, effervescent dosage form, multiple unit oral oral pharmaceutical composition, extended release pharmaceutical dosage form, enteric coated pharmaceutical dosage form, stable pharmaceutical dosage form for oral administration to mammalian subjects, method for treating diseases acid-related diseases by inhibiting gastric acid secretion, method for treating a bacterial infection caused or caused by helicobacter pylori, process for preparing a compound of formula 3, process for preparing a compound of formula 5, use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion, use of a compound of formula 1 for the preparation of a medicament for treating a bacterial infection caused or caused by helicobacter pyl or use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion [P] . BRPI0617987A2 . 2011-08-16

机译：组合物，药物组合物，泡腾剂型，多单位口服口服药物组合物，缓释药物剂型，肠溶衣药物剂型，向哺乳动物受试者口服给药的稳定药物剂型，通过抑制胃酸治疗疾病的方法酸分泌，治疗由幽门螺杆菌引起或引起的细菌感染的方法，制备式3化合物的方法，制备式5化合物的方法，式1化合物在制备用于治疗胃的药物中的用途通过抑制胃酸分泌来治疗与酸有关的疾病，将式1的化合物用于制备用于治疗由幽门螺杆菌引起或引起的细菌感染的药物，或将式1的化合物用于制备用于治疗的药物通过抑制胃酸分泌来治疗胃酸相关疾病
4. a compound, pharmaceutical composition, methods for treating a hepatitis c infection or a condition resulting from a hepatitis c infection in a host in need thereof and for manufacturing a medicament directed for therapeutic use for treating a virus infection of hepatitis c, use of a compound, and pharmaceutical formulation ?. [P] . BR112017018977A2 . 2018-05-22

机译：化合物，药物组合物，用于在有需要的宿主中治疗丙型肝炎感染或丙型肝炎感染引起的疾病的方法，以及用于制备用于治疗丙型肝炎病毒感染的药物的药物，该化合物的用途，以及药物配方？
5. PEPTIDE, PEGUILLED PEPTIDE, COMPOSITION, PHARMACEUTICAL COMPOSITION, BOTTLE, DISINFECTION SOLUTION, METHOD FOR GROWTH INHIBITION, REPLICATION OR INFECTIVITY OF A MICRO-ORGANISM, METHOD FOR INHIBITION OF A BACTERIAL GROWTH, BACTERIAL GROWTH INHIBITION, TREATMENT OF A MICRO-ORGANISM INFECTION IN A SUBJECT AND PREVENTION OF A DISEASE IN A SUBJECT CAUSED BY OR ASSOCIATED WITH A MICRO-ORGANISM INFECTION, METHOD FOR INHIBITING BACTERIAL GROWTH IN A SUBJECT, A METHOD OF TREATMENT OF A BACTERIAL TREATMENT SUBJECT AND TREATMENT OF A DISEASE CAUSED BY OR ASSOCIATED WITH A BACTERIAL INFECTION, METHOD FOR PREVENTING A DISEASE CAUSED BY OR ASSOCIATED WITH A BACTERIAL INFECTION IN A SUBJECT, METHOD FOR INHIBITION OF VIRAL REPLICATION IN A SUBJECT TO A SUBJECT TO A SUBJECT ON A SUBJECT AND TREATMENT OF A DISEASE CAUSED BY OR ASSOCIATED WITH A VIRAL INFECTION IN A SUBJECT, METHOD FOR THE PREVENTION OF A DISEASE CAUSED BY OR ASSOCIATED WITH A VIRAL INFECTION IN A SUBJECT, METHOD FOR DISINFECTING AN INA [P] . BR112017028190A2 . 2018-09-04

机译：肽，规定的肽，成分，药物成分，瓶，消毒溶液，微生物的生长抑制，复制或感染的方法，细菌生长的抑制方法，细菌生长的抑制作用，治疗由微生物感染引起或与之有关的疾病的预防，疾病的抑制方法，一种细菌治疗方法的治疗和一种或多种细菌引起的疾病的治疗感染，预防由细菌感染引起的疾病或与之相关的疾病的方法，在受试者体内抑制病毒复制的方法以及对由细菌引起或与之相关的疾病的治疗在主题中，一种预防由对象中的病毒感染引起或与之相关的疾病的方法，一种用于对INA进行消毒的方法