首页> 中国专利> 一种可以特异性结合并能抑制Tau蛋白聚集的分子及其制备方法和应用

一种可以特异性结合并能抑制Tau蛋白聚集的分子及其制备方法和应用

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摘要

本发明属于抑制蛋白聚集技术领域，具体涉及一种可以特异性结合阿尔茨海默病中的病理性标志物Tau蛋白并能抑制其聚集的探针分子。该类探针分子可以特异性的结合Tau蛋白并能抑制Tau蛋白的聚集，其抑制作用呈现出浓度依赖。本发明的优点在于可以通过调整中间醚链的长度来实现对Tau蛋白单体和聚集体的亲和力，同时醚链的长度对Tau蛋白聚集的抑制能力也有很大影响。

著录项

公开/公告号CN107488144A

专利类型发明专利
公开/公告日2017-12-19

原文格式PDF
申请/专利权人复旦大学;
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申请/专利号CN201710674221.0
发明设计人易涛;吕光磊;魏鹏;李若涵;
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申请日2017-08-09
分类号
代理机构上海正旦专利代理有限公司;
代理人张磊
地址 200433 上海市杨浦区邯郸路220号
入库时间 2023-06-19 04:03:53

法律信息

法律状态公告日

法律状态信息

法律状态
2018-07-06

实质审查的生效 IPC(主分类):C07D215/20 申请日:20170809

实质审查的生效
2017-12-19

公开

公开

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1. 一种可以特异性结合并能抑制Tau蛋白聚集的分子及其制备方法和应用 [P] . 中国专利： CN107488144B . 2021.06.04
2. 一种可以特异性结合并能抑制Tau蛋白聚集的分子及其制备方法和应用 [P] . 中国专利： CN107488144A . 2017-12-19
3. isolated polynucleotide, expression cassette, host cell, isolated polypeptide, non-human transgenic animal that has been altered to express an alkali resistant mutant polypeptide, an antibody that specifically binds to an alkali resistant mutant polypeptide, a mutation detection kit alk inhibitor resistance in a biological sample, and methods for evaluating a biological sample for an alk inhibitor resistance mutation to diagnose cancer that is resistant to or likely to develop resistance to at least one alkaline inhibitor. small alk molecule kinase, to evaluate a biological sample for an alk inhibitor resistance mutation, to diagnose cancer that is resistant to or likely to develop resistance to pf-02341066 in a patient, to specifically reduce expression of an alk-resistant mutant to treat cancer associated with activating aberrant loop capacity that is resistant to at least one small molecule alk kinase inhibitor treating an aberrant cancer that is resistant to pf-02341066, identifyin [P] . BR112012026239A2 . 2018-06-26

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4. Polinucleotu00eddeo insulated tape of expression, host cell, isolated transgenic non-human animal polypeptide, which has been modified to express a polypeptide mutant with resistance to ALK, antibody that binds specifically to a polypeptide mutant with resistance to ALK, kit p For detection of a mutation with resistance to ALK inhibitor in a biological sample, and,Methods for evaluating a biological sample as a mutation with resistance to ALK inhibitor, for diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to evaluate a biological sample that Anto a mutation with resistance to ALK inhibitor.For diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to assess the biological sample as a mutation with resistance to ALK inhibitor, a cancer that is resistant to dianosticar Or is likely to develop resistance to PF - 02341066 in a pati [P] . BR112012026239A2 . 2016-11-29

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5. specific binding agent, hybridoma, conjugate, nucleic acid molecule, vector, host cell, methods of making a specific binding agent, making an antibody, combining unwanted angiogenesis in a mammal, and treating cancer in a mammal, composition methods of modulating or inhibiting angiopoietin-2 activity, modulating at least one of the vascular permeability or plasma leakage in a mammal, treating disease and detecting angiopoietin-2 level in a biological sample, and antibody [P] . BR0213224A . 2007-03-27

机译：特异性结合剂，杂交瘤，缀合物，核酸分子，载体，宿主细胞，制备特异性结合剂的方法，制备抗体，在哺乳动物中组合不需要的血管生成和在哺乳动物中治疗癌症，调节或抑制血管生成素的组合方法-2活性，调节哺乳动物中的血管通透性或血浆渗漏中的至少一种，治疗疾病和检测生物样品中的血管生成素2水平，以及抗体