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一种用于治疗由幽门螺杆菌引起的疾病的囊泡

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摘要

本发明涉及一种用于治疗由幽门螺杆菌感染引起的疾病的囊泡，其中所述囊泡包括：构成囊泡主体的脂质双分子层；以及嵌入在所述脂质双分子层中的用于修复宿主细胞脂筏结构阻断免疫逃逸的胆固醇、幽门螺杆菌敏感性抗生素以及用于恢复自噬溶酶体对细菌降解作用来杀灭胞内幽门螺杆菌的钙三醇；其中，所述脂质为磷脂或/和鼠李糖脂。本发明还涉及一种药物组合物，其包含该治疗由幽门螺杆菌感染引起疾病的囊泡及药学上可接受的载体。本发明的囊泡在能够清除菌膜‑杀死游离菌‑抑制残余菌再黏附的基础上，通过恢复免疫应答并增强胞内菌杀伤作用，进一步提高幽门螺杆菌的清除率。

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公开/公告号CN113908127A

专利类型发明专利
公开/公告日2022-01-11

原文格式PDF
申请/专利权人中山大学;
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申请/专利号CN202010644981.9
发明设计人胡海燕;陈小楠;邹祎晴;李彭宇;饶义琴;
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申请日2020-07-07
分类号A61K9/127(20060101);A61K47/26(20060101);A61K45/06(20060101);A61K31/575(20060101);A61K31/593(20060101);A61K31/43(20060101);A61K31/7048(20060101);A61P31/04(20060101);A61P35/00(20060101);A61P1/04(20060101);
代理机构44348 广州文冠倪律知识产权代理事务所(普通合伙);
代理人杨娅莉
地址 510275 广东省广州市海珠区新港西路135号
入库时间 2023-06-19 13:52:41

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法律状态公告日

法律状态信息

法律状态
2023-01-13

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1. 一种用于治疗由幽门螺杆菌引起的疾病的囊泡 [P] . 中国专利： CN113908127A . 2022-01-11
2. 一种用于治疗由幽门螺杆菌引起的疾病的药物组合物及药物试剂盒 [P] . 中国专利： CN108815159A . 2018-11-16
3. composition, pharmaceutical composition, effervescent dosage form, multiple unit oral oral pharmaceutical composition, extended release pharmaceutical dosage form, enteric coated pharmaceutical dosage form, stable pharmaceutical dosage form for oral administration to mammalian subjects, method for treating diseases acid-related diseases by inhibiting gastric acid secretion, method for treating a bacterial infection caused or caused by helicobacter pylori, process for preparing a compound of formula 3, process for preparing a compound of formula 5, use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion, use of a compound of formula 1 for the preparation of a medicament for treating a bacterial infection caused or caused by helicobacter pyl or use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion [P] . BRPI0617987A2 . 2011-08-16

机译：组合物，药物组合物，泡腾剂型，多单位口服口服药物组合物，缓释药物剂型，肠溶衣药物剂型，向哺乳动物受试者口服给药的稳定药物剂型，通过抑制胃酸治疗疾病的方法酸分泌，治疗由幽门螺杆菌引起或引起的细菌感染的方法，制备式3化合物的方法，制备式5化合物的方法，式1化合物在制备用于治疗胃的药物中的用途通过抑制胃酸分泌来治疗与酸有关的疾病，将式1的化合物用于制备用于治疗由幽门螺杆菌引起或引起的细菌感染的药物，或将式1的化合物用于制备用于治疗的药物通过抑制胃酸分泌来治疗胃酸相关疾病
4. PEPTIDE, PEGUILLED PEPTIDE, COMPOSITION, PHARMACEUTICAL COMPOSITION, BOTTLE, DISINFECTION SOLUTION, METHOD FOR GROWTH INHIBITION, REPLICATION OR INFECTIVITY OF A MICRO-ORGANISM, METHOD FOR INHIBITION OF A BACTERIAL GROWTH, BACTERIAL GROWTH INHIBITION, TREATMENT OF A MICRO-ORGANISM INFECTION IN A SUBJECT AND PREVENTION OF A DISEASE IN A SUBJECT CAUSED BY OR ASSOCIATED WITH A MICRO-ORGANISM INFECTION, METHOD FOR INHIBITING BACTERIAL GROWTH IN A SUBJECT, A METHOD OF TREATMENT OF A BACTERIAL TREATMENT SUBJECT AND TREATMENT OF A DISEASE CAUSED BY OR ASSOCIATED WITH A BACTERIAL INFECTION, METHOD FOR PREVENTING A DISEASE CAUSED BY OR ASSOCIATED WITH A BACTERIAL INFECTION IN A SUBJECT, METHOD FOR INHIBITION OF VIRAL REPLICATION IN A SUBJECT TO A SUBJECT TO A SUBJECT ON A SUBJECT AND TREATMENT OF A DISEASE CAUSED BY OR ASSOCIATED WITH A VIRAL INFECTION IN A SUBJECT, METHOD FOR THE PREVENTION OF A DISEASE CAUSED BY OR ASSOCIATED WITH A VIRAL INFECTION IN A SUBJECT, METHOD FOR DISINFECTING AN INA [P] . BR112017028190A2 . 2018-09-04

机译：肽，规定的肽，成分，药物成分，瓶，消毒溶液，微生物的生长抑制，复制或感染的方法，细菌生长的抑制方法，细菌生长的抑制作用，治疗由微生物感染引起或与之有关的疾病的预防，疾病的抑制方法，一种细菌治疗方法的治疗和一种或多种细菌引起的疾病的治疗感染，预防由细菌感染引起的疾病或与之相关的疾病的方法，在受试者体内抑制病毒复制的方法以及对由细菌引起或与之相关的疾病的治疗在主题中，一种预防由对象中的病毒感染引起或与之相关的疾病的方法，一种用于对INA进行消毒的方法
5. TARGET VESICULAR STRUCTURES FOR CELL PROTECTION AND FOR TREATMENT AGAINST INFECTIONS CAUSED BY HELICOBACTER PYLORI [P] . 俄罗斯专利： RU2207113C2 . 2003-06-27

机译：针对幽门螺杆菌引起的感染的细胞保护和治疗的目标囊泡结构