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一种曲伏前列素眼用组合物及其制备方法

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摘要

本发明涉及一种改进的曲伏前列素眼用组合物及其制备方法，该组合物适应于降低开角型青光眼或高眼压症患者升高的眼压，该组合物在聚丙烯、聚乙烯及玻璃容器中都能够长期稳定存放。利用所公开的组合物，解决了其在制备过程中溶解度低的问题、提高曲伏前列素的稳定性，减少有关物质的形成。该组合物包括曲伏前列素、配合烷基R的碳原子数为12的苯扎氯铵、糖醇和多元醇。该组合物不含吐温80或者聚氧乙烯氢化蓖麻油等非离子表面活性剂。

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公开/公告号CN104873519B

专利类型发明专利
公开/公告日2018-04-27

原文格式PDF
申请/专利权人武汉武药科技有限公司;
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申请/专利号CN201510179274.6
发明设计人吴娟;于艳春;周晶晶;郭婷婷;杨波;
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申请日2015-04-15
分类号
代理机构北京中誉威圣知识产权代理有限公司;
代理人蒋常雪
地址 430074 湖北省武汉市东湖开发区光谷创业街6栋2楼
入库时间 2022-08-23 10:10:10

法律信息

法律状态公告日

法律状态信息

法律状态
2018-04-27

授权

授权
2015-09-30

实质审查的生效 IPC(主分类):A61K31/5575 申请日:20150415

实质审查的生效
2015-09-02

公开

公开

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1. 一种曲伏前列素眼用组合物及其制备方法 [P] . 中国专利： CN104873519B . 2018.04.27
2. 含有曲伏前列素和噻吗洛尔的眼用凝胶剂及其制备方法 [P] . 中国专利： CN103977011B . 2017.04.19
3. use of a compound selected from the group consisting of a proteasome inhibitor, an autophagy inhibitor, a lysosomal inhibitor, an golgi er protein transport inhibitor, an hsp90 chaperonin inhibitor, a heat shock response activator, a and a histone deacetylase inhibitor, use of 11-cis-retinal or 9-cis-retinal and a compound selected from the group consisting of a proteasome inhibitor, an autophagy inhibitor, a lissosomal inhibitor, a er to golgi protein, a hsp90 chaperonin inhibitor, a heat shock response activator, a glycosidase inhibitor, and a histone deacetylase inhibitor, a method for increasing the amount of a biochemically functional conformation of a protein in a cell, composition pharmaceutical for the treatment of an ocular pcd, pharmaceutical composition for the treatment of retinitis pigmentosa, kit for the treatment of an ocular pcd, kit for the treatment retinitis pigmentosa, method for identifying a compound useful for the treatment of an individual having an ocular pcd, [P] . BRPI0615962A2 . 2011-05-31

机译：使用选自以下的化合物：蛋白酶体抑制剂，自噬抑制剂，溶酶体抑制剂，高尔基体蛋白转运抑制剂，hsp90伴侣蛋白抑制剂，热休克反应激活剂，α和组蛋白脱乙酰酶抑制剂，使用11 -顺式-视黄醛或9-顺式-视黄醛以及选自蛋白酶体抑制剂，自噬抑制剂，核糖体抑制剂，高尔基体蛋白er，hsp90伴侣蛋白抑制剂，热休克反应激活剂，糖苷酶的化合物抑制剂和组蛋白脱乙酰基酶抑制剂，一种增加细胞中蛋白质的生化功能构象量的方法，用于治疗眼pcd的组合物药物，用于治疗色素性视网膜炎的药物组合物，用于治疗视网膜色素变性的试剂盒眼用pcd，用于治疗色素性视网膜炎的试剂盒，用于鉴定可用于治疗具有眼用pcd的个体的化合物的方法，
4. Compositions, compositions in anhydrous structured, anhydrous compositions comprising at least one heteropolu00ecmero and at least a load inert, mask, Eyeliner eyes, foundation, lipstick, blush.The product of the removal of makeup, make-up product for the body, eye shadow, face powder, the product dissimilador, shampoo, conditioner,The product sunscreen or care for the lips or hair product deodorant or care for the skin, lips and body.The composition of the care and / or treatment and / or makeup for fibers queratu00ecnicas, lips or skin, the composition in the form of a lip stick, the composition of eye shadow, composition lip,The basic composition, method of care, make-up or treatment of fibers queratu00ecnicas, lips or skin, method of providing anhydrous composition, structured composition, composition for makeup.Care or treatment to the skin, lips or queratu00ecnicas fibres, method for makeup or care for the skin, lips or fibers queratu00ecnicas, composition of makeup in the [P] . BR0108298A . 2003-03-05

机译：组合物，无水结构的无水组合物中的组合物，其包含至少一种杂粉，至少一种负载惰性，面膜，眼线笔眼，粉底，口红，腮红。卸妆产品，用于人体的彩妆产品，眼影，粉饼，产品不当产品，洗发水，护发素，产品防晒霜或护唇产品或头发产品除臭剂或护理皮肤，嘴唇和身体的护理和/或治疗和/或治疗的成分纤维雀斑，嘴唇或皮肤的化妆品，口红形式的成分，眼影的成分，嘴唇成分，基本成分，护理方法，化妆或治疗纤维雀斑，嘴唇或皮肤，提供无水组合物的方法，结构化组合物，化妆用组合物。对皮肤，嘴唇或栎类纤维的护理或治疗，皮肤，嘴唇或纤维的化妆或护理方法的
5. Anhydrous compositions, compositions containing at least one heteropolu00ecmero and at least one agent gelatinante, mascara, Eyeliner eyes, foundation, lipstick, blush, the product of makeup removal.Make-up product for the body, eye shadow, face powder, the product masking, shampoo, conditioner, product sunscreen or care for the skin, lips and hair.Deodorant product or product of skin care and body composition of care and / or treatment and / or makeup for fibers queratu00ecnicas, lips or skin.The composition of the care and / or treatment and / or makeup for materials queratu00ecnicos, composition of lipstick in the form of a stick, method of care, make-up or materials processing queratu00ecnicos,The method of care, make-up or treatment of fibers queratu00ecnicas, lips or skin, method of providing anhydrous composition, structured composition, composition for makeup.Care or treatment to the skin, lips or queratu00ecnicas fibres and method of makeup or care for the skin, lips [P] . BR0108381A . 2002-10-29

机译：无水组合物，包含至少一种异波罗蜜和至少一种药剂明胶，睫毛膏，眼线笔眼，粉底，口红，腮红，卸妆产品的组合物。身体彩妆产品，眼影，粉饼，产品遮盖剂，洗发水，护发素，产品防晒霜或皮肤，嘴唇和毛发护理。皮肤或皮肤护理产品的除臭剂或产品的护理和/或治疗和/或化妆用，以抑制皮肤，嘴唇或皮肤的皱纹。。原料Quratec的护理和/或治疗和/或化妆的成分，棒状口红的成分，保养方法，化妆或原料加工Quratec的护理方法，骨，嘴唇或皮肤的纤维的化妆或治疗，提供无水组合物，结构化组合物，化妆用组合物的方法，皮肤，嘴唇或que骨的纤维的护理或治疗以及皮肤或嘴唇的化妆或护理的方法皮肤，嘴唇