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CDK6小分子抑制剂在降低肝癌细胞对抗肿瘤药或放疗的耐受性中的应用

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摘要

本发明涉及CDK6小分子抑制剂在降低肝癌细胞对抗肿瘤药或放疗的耐受性中的应用，属于医药领域。现有技术肝癌特别是晚期肝癌对抗肿瘤药耐受性高，基于此，本发明公开CDK6小分子抑制剂在降低肝癌细胞对抗肿瘤药或放疗的耐受性中的应用。本发明证实了肝癌细胞对于抗肿瘤药物的耐受性与CDK6的表达呈现正相关性，使用CDK6小分子抑制剂可以显著降低肝癌细胞的CDK6表达水平，其适用于处于不同发展期的肝癌细胞和不同类型的肝癌细胞。更进一步的，其可以与常用抗肿瘤药组成组合物用于肝癌的治疗中，极大地提高了药物的治疗效果和患者的生存率。

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公开/公告号CN108524938B

专利类型发明专利
公开/公告日2020-06-19

原文格式PDF
申请/专利权人深圳大学;
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申请/专利号CN201810621536.3
发明设计人陈家杰;吉坤美;常港;蔡楠;
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申请日2018-06-15
分类号A61K45/06(20060101);A61K31/506(20060101);A61K31/513(20060101);A61P35/00(20060101);
代理机构44416 广州科沃园专利代理有限公司;
代理人黄健仪
地址 518060 广东省深圳市南山区南海大道3688号
入库时间 2022-08-23 11:02:23

法律信息

法律状态公告日

法律状态信息

法律状态
2020-06-19

授权

授权
2018-10-16

实质审查的生效 IPC(主分类):A61K45/06 申请日:20180615

实质审查的生效
2018-09-14

公开

公开

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1. CDK6小分子抑制剂在降低肝癌细胞对抗肿瘤药或放疗的耐受性中的应用 [P] . 中国专利： CN108524938B . 2020.06.19
2. CDK6小分子抑制剂在降低肝癌细胞对抗肿瘤药或放疗的耐受性中的应用 [P] . 中国专利： CN108524938A . 2018-09-14
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