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一种制备Tubulysin关键片段Tuv的方法

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摘要

本发明属于化学合成技术领域，涉及一种制备具有抗癌活性天然产物Tubulysin的关键片段Tuv的方法。本发明方法操作简单，路线简洁，收率较高，尤其本发明方法的技术路线高选择性、可放大制备Tubulysin V的Tuv片段。本发明方法制得的具有抗癌活性天然产物Tubulysin的关键片段Tuv有助于该类化合物的成药性评价及临床前评价。

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公开/公告号CN110684044B

专利类型发明专利
公开/公告日2022.08.26

原文格式PDF
申请/专利权人复旦大学;
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申请/专利号CN201810748596.1
发明设计人魏邦国;王雪梅;毛卓亚;周祝;汪晨;聂晓迪;林国强;
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申请日2018.07.06
分类号C07F7/18(2006.01);C07D207/273(2006.01);C07D207/12(2006.01);
代理机构上海元一成知识产权代理事务所(普通合伙) 31268;
代理人吴桂琴
地址 200433 上海市邯郸路220号
入库时间 2022-09-26 23:16:43

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1. 一种制备Tubulysin关键片段Tuv的方法 [P] . 中国专利： CN110684044A . 2020-01-14
2. 一种天然抗癌药物Tubulysins的关键中间体Tuv的合成方法 [P] . 中国专利： CN111454230B . 2021-12-14
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机译：青霉素结合蛋白，核酸，抗体或抗体片段，药物，药物组合物，至少一种青霉素结合蛋白或其片段或变异体或片段，至少一种核酸和至少一种抗体或抗体片段的用途，针对脑膜炎奈瑟菌的青霉素结合蛋白，核酸，抗体或抗体片段感染的体外抗体检测方法，至少一种青霉素结合蛋白或其片段或变异体或变异体，至少一种核酸的药物组合物酸和至少一种针对哺乳动物生物样品中脑膜炎奈瑟氏菌感染的抗体以及来自哺乳动物生物样品中的矿业性奈瑟氏球菌感染的体外诊断和单克隆抗体
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