首页> 外国专利> METHOD OF PRODUCING 2-AMINO-9-AROYL-8-HYDROXY-6-(2-HYDROXYPHENYL)-1-THIA-3,6-DIAZASPIRO4.4NONA-2,8-DIENE-4,7-DIONE

METHOD OF PRODUCING 2-AMINO-9-AROYL-8-HYDROXY-6-(2-HYDROXYPHENYL)-1-THIA-3,6-DIAZASPIRO4.4NONA-2,8-DIENE-4,7-DIONE

机译：制备2-氨基-9-芳基-8-羟基-6-（2-羟基苯氧基）-1-硫代-3,6-二氮杂螺[4.4] NONA-2,8-二烯-4,7-二酮的方法

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FIELD: chemistry.;SUBSTANCE: invention relates to a method of producing 2-amino-9-aroyl-8-hydroxy-6-(2-hydroxyphenyl)-1-thia-3,6-diazaspiro[4.4]nona-2,8-dien-4,7-dione , which can be used as initial products for synthesis of novel heterocyclic systems and in pharmacology. 2-amino-9-aroyl-8-hydroxy-6-(2-hydroxyphenyl)-1-thia-3,6-diazaspiro[4.4]nona-2,8-diene-4,7-diones represented by formula (II), where Ar=Ph, R=Cl (a); Ar=C₆H₄Cl-4, R=H (b), Ar=C₆H₄Me-4, R=H (c) is obtained by reacting 3-aroylpyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones of formula (I) with thiourea in a medium of an inert aprotic solvent, followed by separation of desired products. ; ;EFFECT: synthesis of 2-amino-9-aroyl-8-hydroxy-6-(2-hydroxyphenyl)-1-thia-3,6-diazaspiro[4.4]nona-2,8-diene-4,7-diones, having antimicrobial activity.;1 cl, 1 tbl, 4 ex;а - a;в - c

机译：发明领域：本发明涉及一种制备2-氨基-9-芳酰基-8-羟基-6-（2-羟基苯基）-1-硫杂3,6-二氮杂螺[4.4] nona-2的方法， 8-dien-4,7-dione，可用作合成新型杂环系统和药理学的初始产物。由式（II）表示的2-氨基-9-芳酰基-8-羟基-6-（2-羟基苯基）-1-硫杂3,6-二氮杂螺[4.4]壬娜-2,8-二烯-4,7-二酮），其中Ar = Ph，R = Cl（a）; Ar = C _{6 H _{4 Cl-4，R = H（b），Ar = C _{6 H _{4 Me-4，R = H（c）是通过将式（I）的3-芳基吡咯并[2,1-c] [1,4]苯并恶嗪-1,2,4-三酮与硫脲在惰性非质子溶剂，然后分离所需产物。 ; ;作用：合成2-氨基-9-芳酰基-8-羟基-6-（2-羟基苯基）-1-硫杂3,6-二氮杂螺[4.4] nona-2,8-diene-4,7-diones ;具有抗菌活性。; 1 cl，1 tbl，4 ex;а-a;в-c}}}}

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公开/公告号RU2707195C1

专利类型
公开/公告日2019-11-25

原文格式PDF
申请/专利权人 FEDERALNOE GOSUDARSTVENNOE BYUDZHETNOE OBRAZOVATELNOE UCHREZHDENIE VYSSHEGO OBRAZOVANIYA PERMSKIJ GOSUDARSTVENNYJ NATSIONALNYJ ISSLEDOVATELSKIJ UNIVERSITET;
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申请/专利号RU20190119733
发明设计人 MASLIVETS ANDREJ NIKOLAEVICH (RU);KOBELEV ALEKSANDR IVANOVICH (RU);STEPANOVA EKATERINA EVGENEVNA (RU);BALANDINA SVETLANA YUREVNA (RU);
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申请日2019-06-24
分类号C07D513/10;A61P31/04;
国家 RU
入库时间 2022-08-21 11:02:49

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