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PCL PEG PCL and PEG patch scaffold for tissue regeneration and preparing method thereof

机译:用于组织再生的pcl peg PCl和peg贴片支架及其制备方法

摘要

The present invention relates to a tissue regeneration support for PCL and PEG patches and a method for manufacturing the same, and more specifically, polycaprolactone is added and stirred after adding polycaprolactone (PCL) and polyethylene glycol (PEG) and an acid to an organic solvent. -Preparing a polyethylene glycol copolymer solution; Preparing an electrospinning solution by adding a growth factor to the solution and then stirring; And connecting the prepared electrospinning solution to a pump, and then operating the electrospinning device to collect nanofibers arranged in a spindle shape on the collector; providing a method of manufacturing a PCL and PEG patch tissue regeneration support. PCL and PEG patch tissue regeneration support according to the present invention can be usefully used for the treatment of acute and chronic tympanic perforation, in particular, to reduce the proportion of surgery in the treatment method that relies on surgery for the treatment of chronic tympanic perforation and show a high recovery rate of the eardrum You can. In addition, the PCL and PEG patch tissue regeneration support can be applied to regeneration and treatment of other damaged tissues, and it is possible to develop and apply various tissue regeneration supports by simulating the tissue structure of different parts of the human body.
机译:本发明涉及用于PCL和PEG贴剂的组织再生支持物及其制造方法,更具体地讲,在将聚己内酯(PCL)和聚乙二醇(PEG)和酸添加至有机溶剂中之后,添加并搅拌聚己内酯。 。 -制备聚乙二醇共聚物溶液;通过向溶液中添加生长因子然后搅拌来制备静电纺丝溶液;将制备的静电纺丝溶液连接至泵,然后操作静电纺丝装置,将呈纺锤形排列的纳米纤维收集在收集器上。提供了一种制造PCL和PEG贴片组织再生支持物的方法。根据本发明的PCL和PEG贴片组织再生支持物可有效地用于治疗急性和慢性鼓膜穿孔,尤其是在依赖于用于治疗慢性鼓膜穿孔的手术的治疗方法中减少手术的比例并显示出较高的耳膜恢复率。另外,PCL和PEG贴片组织再生支持物可以应用于其他受损组织的再生和治疗,并且可以通过模拟人体不同部位的组织结构来开发和应用各种组织再生支持物。

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