The present invention relates to a method and a composition for preparing a novel resolbin D2 analogue using two kinds of lipoxygenases. According to the present invention, 8-lipoxygenase derived from Mus musculus mice And by using 15-lipoxygenase from Burkholderia thailandensis strain, new resolbin analogs not reported to date in an environmentally friendly manner can be produced with high productivity and high yield, It can be usefully used in various industries such as food and cosmetics.
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