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Methods and compositions for detecting and promoting cardiolipin remodeling and cardiomyocyte maturation and related methods for treating mitochondrial dysfunction
Methods and compositions for detecting and promoting cardiolipin remodeling and cardiomyocyte maturation and related methods for treating mitochondrial dysfunction
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机译：检测和促进心磷脂重构和心肌细胞成熟的方法，组合物以及治疗线粒体功能障碍的相关方法
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摘要
Embodiments of the present disclosure relate to methods and compositions for inducing maturation of cardiomyocytes. In some embodiments, the cardiomyocyte is derived from stem cells in vitro. In some embodiments, the compositions and methods promote maturation by inducing overexpression of Let7i microRNA (miRNA), overexpression of miR-452, reduced expression of miR-122, and/or reduced expression of miR-200a in cardiomyocytes. To induce. In another embodiment, the present disclosure relates to a method of treating a condition characterized by mitochondrial dysfunction, such as a fatty acid oxidation disorder. In another embodiment, the present disclosure relates to a method of screening for compounds that affect cardiac muscle function. In another embodiment, the present disclosure relates to a method of detecting or monitoring mitochondrial dysfunction in a cell by detecting or monitoring the cardiolipin profile of the cell.
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