首页> 外国专利> METHODS AND COMPOSITIONS FOR DETECTING AND PROMOTING CARDIOLIPIN REMODELING AND CARDIOMYOCYTE MATURATION AND RELATED METHODS OF TREATING MITOCHONDRIAL DYSFUNCTION

METHODS AND COMPOSITIONS FOR DETECTING AND PROMOTING CARDIOLIPIN REMODELING AND CARDIOMYOCYTE MATURATION AND RELATED METHODS OF TREATING MITOCHONDRIAL DYSFUNCTION

机译：用于检测和促进心肌脂肪素重塑和心肌细胞成熟的方法和组合物及治疗线粒体功能障碍的相关方法

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摘要

Embodiments of the disclosure relate to methods and compositions for inducing maturation of cardiomyocytes. In some embodiments, the cardiomyocytes are derived from stem cells, in vitro. In some embodiments, the compositions and methods induce maturation by inducing overexpression of a Let7i microRNA (miRNA), overexpression of miR-452, reduced expression of miR-122, and/or reduced expression of miR-200a in the cardiomyocyte. In other embodiments, the disclosure relates to methods for treating conditions characterized by mitochondrial dysfunction, such as fatty acid oxidations disorders. In other embodiments, the disclosure relates to methods of screening for compounds that affect heart muscle function. In yet other embodiments, the disclosure relates to methods for detecting or monitoring mitochondrial dysfunction in a cell by detecting or monitoring the cardiolipin profile of the cell.

机译：本公开的实施方案涉及用于诱导心肌细胞成熟的方法和组合物。在一些实施方案中，心肌细胞衍生自干细胞，体外。在一些实施方案中，组合物和方法通过诱导Let7i microRNA（miRNA）的过度表达，miR-452的过表达，减少miR-122的表达，和/或在心肌细胞中减少miR-200a的表达而诱导成熟。在其他实施方案中，本公开涉及治疗特征的病症的方法，例如线粒体功能障碍，例如脂肪酸氧化疾病。在其他实施方案中，本公开涉及筛选影响心肌功能的化合物的方法。在其他实施方案中，本公开涉及通过检测或监测细胞的心胃脂谱来检测或监测细胞中的线粒体功能障碍的方法。

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公开/公告号EP3720455A4

专利类型
公开/公告日2021-09-22

原文格式PDF
申请/专利权人 THE UNIVERSITY OF WASHINGTON;
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申请/专利号EP20180885394
发明设计人 MIKLAS JASON WAYNE;RUOHOLA-BAKER HANNELE;WANG YULIANG;
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申请日2018-12-07
分类号A61K35/34;A61K35/44;A61K48;C12N5/077;C12N5/16;C12N5/22;C12N15/06;C12N15/07;C12N15/11;C12N15/113;G01N33/50;
国家 EP
入库时间 2022-08-24 21:11:34

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