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EGFR Composition for preventing or treating non small cell lung cancer harboring the EGFR mutations
EGFR Composition for preventing or treating non small cell lung cancer harboring the EGFR mutations
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机译:用于预防或治疗具有EGFR突变的非小细胞肺癌的EGFR组合物
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摘要
The present invention relates to a composition for preventing, alleviating or treating non-small cell lung cancer harboring an EGFR-mutation, including a JNK (c-Jun N-terminal kinase) activator as an active ingredient. The composition for preventing, alleviating or treating non-small cell lung cancer harboring an EGFR-mutation significantly reduces the level of EGFR in the cells of non-small cell lung cancer harboring an EGFR-mutation to induce apoptosis, and thus can be useful for preventing, alleviating or treating non-small cell lung cancer. Particularly, it is possible to effectively treat and prevent non-small cell lung cancer on which gefitinib or erlotinib has no effect. The present invention also provides a composition for inhibiting resistance of non-small cell lung cancer against an EGFR tyrosine kinase inhibitor, and the composition allows effective conquest of resistance against an EGFR tyrosine kinase inhibitor.
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