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EGFR Composition for preventing or treating non small cell lung cancer harboring the EGFR mutations

机译:用于预防或治疗具有EGFR突变的非小细胞肺癌的EGFR组合物

摘要

The present invention relates to a composition for preventing, alleviating or treating non-small cell lung cancer harboring an EGFR-mutation, including a JNK (c-Jun N-terminal kinase) activator as an active ingredient. The composition for preventing, alleviating or treating non-small cell lung cancer harboring an EGFR-mutation significantly reduces the level of EGFR in the cells of non-small cell lung cancer harboring an EGFR-mutation to induce apoptosis, and thus can be useful for preventing, alleviating or treating non-small cell lung cancer. Particularly, it is possible to effectively treat and prevent non-small cell lung cancer on which gefitinib or erlotinib has no effect. The present invention also provides a composition for inhibiting resistance of non-small cell lung cancer against an EGFR tyrosine kinase inhibitor, and the composition allows effective conquest of resistance against an EGFR tyrosine kinase inhibitor.
机译:本发明涉及一种预防,减轻或治疗具有EGFR突变的非小细胞肺癌的组合物,其包含JNK(c-Jun N-末端激酶)活化剂作为活性成分。用于预防,减轻或治疗具有EGFR突变的非小细胞肺癌的组合物显着降低了具有EGFR突变的非小细胞肺癌的细胞中诱导细胞凋亡的EGFR水平,因此可用于预防,缓解或治疗非小细胞肺癌。特别地,可以有效地治疗和预防吉非替尼或厄洛替尼对其无效的非小细胞肺癌。本发明还提供了用于抑制非小细胞肺癌对EGFR酪氨酸激酶抑制剂的抗性的组合物,并且该组合物允许有效征服对EGFR酪氨酸激酶抑制剂的抗性。

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