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RWL-1 Pharmaceutical composition for preventing or treating gastrointestinal disorder comprising as an active ingredient a compound isolated from Bacillus amyloliquefaciens RWL-1 culture medium
RWL-1 Pharmaceutical composition for preventing or treating gastrointestinal disorder comprising as an active ingredient a compound isolated from Bacillus amyloliquefaciens RWL-1 culture medium
The present invention relates to a composition for preventing, solving, and treating gastrointestinal diseases comprising a compound isolated from a culture medium of Bacillus amyloliquefaciens RWL-1 strain and is the first to describe the enzyme inhibitory activity of a bioactive compound isolated from Bacillus amyloliquefaciens species. Since the compound of the present invention has excellent urease inhibitory activity, the compound has an effect of inhibiting the urease activity of Helicobacter pylori and making Helicobacter pylori difficult to survive in the gastric mucosa. Therefore, the compound is effective for treating, preventing, and solving gastrointestinal diseases. The compound uses a secondary metabolite of microorganisms and is expected to be useful in the medical and food industries by using it as an important source of a bioactive metabolite with high therapeutic value.
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