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GENERATION OF FUNCTIONAL AND PATIENT-SPECIFIC THYMIC TISSUE IN VIVO FROM INDUCED PLURIPOTENT STEM CELLS
GENERATION OF FUNCTIONAL AND PATIENT-SPECIFIC THYMIC TISSUE IN VIVO FROM INDUCED PLURIPOTENT STEM CELLS
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机译：从诱导的多能干细胞体内产生功能性和患者特异性胸腺组织
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摘要
The disclosed technology includes methods, systems, and devices for generating patient-specific functional thymic epithelial progenitor (TEP) cells. In some implementations, a method may include generating iPSCs from HSC; causing differentiation of the iPSC into thymic epithelial progenitor (TEP) cells, generating thymic epithelial cells by transplantation of the TEP cells into a host, wherein the TEP cells may differentiate into mature functional thymic epithelial cells (TECs). In some implementations, a system may include a cell population of patient specific cells, a population of iPSCs, a culture system for differentiating the iPSCs into a population of patient-specific TEP cells for transfer to a host or the patient to allow the TEP cells to differentiate into mature, functional TEC.
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