首页> 外国专利> GENETICALLY MODIFIED BACTERIA PRODUCING THREE DNA REPAIR ENZYMES AND METHOD FOR THE EVALUATION OF DNA REPAIR ACTIVITY

GENETICALLY MODIFIED BACTERIA PRODUCING THREE DNA REPAIR ENZYMES AND METHOD FOR THE EVALUATION OF DNA REPAIR ACTIVITY

机译：生产三种DNA修复酶的基因修饰细菌及其DNA修复活性的评价方法

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摘要

The present invention provides three recombinant E. coli strains for the production of the enzymes CPD-photolyase, 6,4-bifunctional photolyase and 6,4-photolyase, from bacterial Antarctic isolates of the genus Hymenobacter the first one and Sphingomonas the others. Also provides the process of production and purification of the recombinant enzymes with high performance, high degree of purity and high catalytic repair activity, having applications in, but it is not limited to, cosmetics and pharmaceutical industry. Other aspect of this invention is to provide a fast, cheap and qualitative method for the determination of the CPD-photolyase activity.

机译：本发明提供了三种重组大肠杆菌菌株，用于从第一个猪门菌属的细菌南极分离物和其他鞘氨醇单胞菌属中产生CPD-光解酶，6,4-双功能光解酶和6,4-光解酶。还提供了具有高性能，高纯度和高催化修复活性的重组酶的生产和纯化方法，其在化妆品和制药工业中具有应用，但不限于此。本发明的另一方面是提供一种用于测定CPD-光裂解酶活性的快速，廉价和定性的方法。

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公开/公告号WO2020047637A1

专利类型
公开/公告日2020-03-12

原文格式PDF
申请/专利权人 UNIVERSIDAD DE LA REPUBLICA;DE CENÇO NASCIMENTO MARIA CLAUDIA;MINISTERIO DE DEFENSA NACIONAL - INSTITUTO ANTÁRTICO URUGUAYO;
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申请/专利号WO2019BR50373
发明设计人 MARIZCURRENA JUAN JOSÉ;CASTRO SOWINSKI SUSANA;
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申请日2019-09-04
分类号C12N9/88;C12N15/60;C12N15/70;C12N1/21;C12Q1/527;C12Q1/683;C12R1/19;C12R1/20;
国家 WO
入库时间 2022-08-21 11:13:01

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