首页> 外国专利> 4-(P-TRIFLUOROMETHYLBENZYL)-3-FLORO-1,2,4 TRIPHENYLAMINE DERIVATIVE, PHARMACEUTICAL COMPOSITION OF SAME, AND USES THEREOF

4-(P-TRIFLUOROMETHYLBENZYL)-3-FLORO-1,2,4 TRIPHENYLAMINE DERIVATIVE, PHARMACEUTICAL COMPOSITION OF SAME, AND USES THEREOF

机译：4-（对-三氟甲基苄基）-3-氟-1,2,4三苯胺衍生物，相同组成的药物组成及其用途

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摘要

Provided in the present invention are a 4-(p-trifluoromethylbenzyl)-3-floro-1,2,4 triphenylamine derivative, a pharmaceutical composition of same, and uses thereof. The chemical formula of the derivative is as represented by formula I, where R is a C₁-C₆ alkyl, a cycloalkyl, a heteroatom-containing cycloalkyl, an aromatic ring, or a heteroatom-containing aromatic ring, the heteroatom is selected from N or O; n is 0, 1, 2, or 3; and the pharmaceutical composition has any of the 4-(p-trifluoromethylbenzyl)-3-floro-1,2,4 triphenylamine derivatives described above as the active ingredient and, at the same time, contains one or more pharmaceutically acceptable carrier. The derivative and the pharmaceutical composition are provided with a significantly activated KCNQ channel current; therefore, the derivative is applicable in preparing a KCNQ potassium channel opener, also applicable as an active ingredient of an antiepileptic medicinal preparation, and as an active ingredient of an anxiety relieving medicinal preparation and of a neuropathic pain relieving medicinal preparation.

机译：本发明提供了一种4-（对三氟甲基苄基）-3-氟-1,2,4三苯胺衍生物，其药物组合物及其用途。衍生物的化学式如式I所示，其中R为C 1 -Sub 1 -C 6 -Sub烷基，环烷基，含杂原子的环烷基，芳环。，或含杂原子的芳环，杂原子选自N或O; n为0、1、2或3;所述药物组合物具有上述的4-（对三氟甲基苄基）-3-氟-1,2,4三苯胺衍生物中的任一种作为活性成分，并且同时包含一种或多种药学上可接受的载体。衍生物和药物组合物具有显着活化的KCNQ通道电流。因此，该衍生物适用于制备KCNQ钾通道开放剂，也可用作抗癫痫药物制剂的活性成分，以及作为缓解焦虑的药物制剂和缓解神经性疼痛的药物制剂的活性成分。

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公开/公告号WO2020001298A1

专利类型
公开/公告日2020-01-02

原文格式PDF
申请/专利权人 HEBEI MEDICAL UNIVERSITY;
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申请/专利号WO2019CN91365
发明设计人 ZHANG HAILIN;QI JINLONG;JIA QINGZHONG;DU XIAONA;HAO HAN;
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申请日2019-06-14
分类号C07C231/02;C07C233/43;C07C233/44;C07D295/15;C07D307/54;C07D211/34;A61K31/167;A61K31/4465;A61K31/341;A61P25/08;A61P25/22;A61P29;A61P25/02;
国家 WO
入库时间 2022-08-21 11:14:05

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