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AMPHIPHILIC AMINOGLYCOSIDE CONNEXIN HEMICHANNEL INHIBITORS

机译：两性氨基糖苷连接蛋白半通道抑制剂

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摘要

The present invention includes novel molecules and methods of using an amphiphilic kanamycin molecule having substitutions at the O-4", 0-6", or O-4" and 0-6" positions having reduced antimicrobial activity for targeting Connexin Hemichannels.

机译：本发明包括新颖的分子和使用在 O -4”，0-6”或 O -4”和0-处具有取代基的两亲卡那霉素分子的方法。具有降低的针对连接蛋白半通道的抗菌活性的6英寸位置。 展开▼

著录项

公开/公告号WO2019241348A9

专利类型

公开/公告日2020-02-27

原文格式PDF

申请/专利权人 TEXAS TECH UNIVERSITY SYSTEM;
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申请/专利号WO2019US36714

发明设计人 ALTENBERG GUILLERMO A.;CHANG CHENG-WEI TOM;
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申请日2019-06-12

分类号A01N1/02;

国家 WO

入库时间 2022-08-21 11:14:10

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1. 用于靶向连接蛋白半通道的组合物和方法 [P] . 中国专利： CN106659909B . 2022.01.11

2. 连接蛋白(Cx)43半通道结合抗体及其用途 [P] . 中国专利： CN109071642A . 2018-12-21

3. AMPHIPHILIC AMINOGLYCOSIDE CONNEXIN HEMICHANNEL INHIBITORS [P] . 世界知识产权组织专利： WO2019241348A1 . 2019-12-19

机译：两性氨基糖苷连接蛋白半通道抑制剂

4. Antibodies to connexin 43 (Cx43) hemichannels and methods of use thereof to inhibit Cx43 hemichannel opening [P] . 美国专利： US10633442B2 . 2020-04-28

机译：连接蛋白43（Cx43）半通道的抗体及其使用抑制Cx43半通道开放的方法

5. Method for identifying compounds that inhibit specific connexin hemichannels and use of those inhibitors to treat and / or prevent inflammatory diseases, vascular disorders, arrhythmia, Chronic wounds, neuroprotection of retinal Fibrosis and pain. [P] . CL2014001556A1 . 2014-10-03

机译：鉴定抑制特定连接蛋白半通道的化合物的方法，以及使用这些抑制剂治疗和/或预防炎症性疾病，血管疾病，心律不齐，慢性伤口，视网膜纤维化和疼痛的神经保护方法。

1. Connexin therapeutics: blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions [J] . Monica L. Acosta, Mohd N. Mat Nor, Cindy X. Guo, 中国神经再生研究（英文版） . 2021,第003期

2. Mechanotransduction via the coordinated actions of integrins,PI3K signaling and Connexin hemichannels [J] . Manuel A.Riquelme, Sumin Gu, Rui Hua, 骨研究：英文 . 2021,第001期

3. Mechanotransduction via the coordinated actions of integrins, PI3K signaling and Connexin hemichannels [J] . Manuel A.Riquelme, Sumin Gu, Rui Hua, 骨研究（英文版） . 2021,第001期

4. Connexin 43 hemichannels protect bone loss during estrogen deficiency [J] . Liang Ma, Jean X. Jiang, Rui Hua, 骨研究（英文版） . 2019,第002期

5. Connexin 43 hemichannels protect bone loss during estrogen deficiency [J] . Liang Ma, Rui Hua, Yi Tian, 骨研究：英文 . 2019,第002期

6. Inhibition of Connexin Hemichannels by New Amphiphilic Aminoglycosides without Antibiotic Activity [J] . MadherN. AlFindee, Yagya P. Subedi, Mariana C. Fiori, ACS medicinal chemistry letters . 2018,第7期

7. Connexin hemichannel inhibitors with a focus on aminoglycosides [J] . Natha Cristina M., Vemulapalli Varun, Fiori Mariana C., Biochimica et biophysica acta. Molecular basis of disease: BBA . 2021,第6期

8. Inhibition by Commercial Aminoglycosides of Human Connexin Hemichannels Expressed in Bacteria [J] . Mariana Fiori, Srinivasan Krishnan, Abbey Kjellgren, Molecules . 2017,第12期

9. Amphiphilic Wax Inhibitor for Tackling Crude Oil Wax Deposit Challenges [C] . Zongming Xiu, Pierre-Emmanuel Dufils, Jia Zhou SPE International Conference on Oilfield Chemistry . 2019

10. Mechanisms of connexin gating and permeability revealed by connexin46 hemichannels. [D] . Trexler, Edmund Brady. 2000

11. Inhibition by Commercial Aminoglycosides of Human Connexin Hemichannels Expressed in Bacteria [O] . Mariana C. Fiori, Srinivasan Krishnan, Abbey Kjellgren, 2017

12. Inhibition by Commercial Aminoglycosides of Human Connexin Hemichannels Expressed in Bacteria [O] . Mariana C. Fiori, Srinivasan Krishnan, Abbey Kjellgren, 2017

1. 连接蛋白43及其半通道在大鼠全脑缺血再灌注损伤中的作用 [C] . 马爱华 ,王学禹 ,孙文秀 . 第十五届全国儿科神经学术会议 . 2013

2. 缝隙连接蛋白Connexin 43半通道在H9c2细胞增殖调节中的作用及机制 [A] . 宋东莉 . 2010