首页> 外国专利> ELECTROSPUN FIBERS FOR A LOCAL RELEASE OF AN ANTI-INFLAMMATORY DRUG AND A PROMYELINATING DRUG

ELECTROSPUN FIBERS FOR A LOCAL RELEASE OF AN ANTI-INFLAMMATORY DRUG AND A PROMYELINATING DRUG

机译:电纺纤维局部释放抗炎药和早孕药

摘要

The present invention relates to electrospun fibers for a local release in the central nervous system of an anti-inflammatory and a promyelinating agent over a defined time-window, in order to limit secondary neurodegeneration triggered by the glutamate release and supported by on-going inflammation. The combined treatment aimed to reduce inflammation and improve remyelination in the very early stage of the pathology improving the chronic clinical outcome of the lesion. In particular the present invention relates to electrospun polymeric fibers, wherein said fibers are loaded with 3,3,5-Triiodo-L-thyronine (T3) and Ibuprofen.
机译:本发明涉及用于在限定的时间内在中枢神经系统中局部释放抗炎剂和早髓鞘剂的电纺丝纤维,以限制由谷氨酸释放触发并由持续的炎症支持的继发性神经变性。 。联合治疗旨在在病理的非常早期减少炎症并改善髓鞘再生,改善病变的慢性临床结局。特别地,本发明涉及电纺聚合物纤维,其中所述纤维负载有3,3,5-三碘代-L-甲状腺氨酸(T3)和布洛芬。

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