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System for preclinical determination of permeation rate of biologically active agents to be administered percutaneously, in particular drugs, and device for measuring permeation rate of biologically active agents to be administered percutaneously, in particular drugs
System for preclinical determination of permeation rate of biologically active agents to be administered percutaneously, in particular drugs, and device for measuring permeation rate of biologically active agents to be administered percutaneously, in particular drugs
The purpose of the notification is to determine the pre-clinical dynamics of the penetration of bioactive agents for intradermal administration, in particular medicinal products, and to measure the penetration dynamics of bioactive agents for intradermal administration, a device to measure the contact points of the liquid drop with the surface of the membrane containing the base,where the membrane is placed,the contact point recorder of the sample liquid on the membrane is characterised by the fact that the base is made in the form of a shield (20a) with the possibility of rotating around its own axis (20b),and in addition, teeth are made on the edges of the shield between which at least three slots are formed and a detachable measuring vessel is placed in each layer (22),and in addition, a platform (24) equipped with an outlet (25) at least partially above the shield (20a) and a sample fluid transmitter, with the outlet (25) connected to the rotating module (26) giving it rotation, is equipped with a moving vertical axis; where the exhaust manifold is so made that, when the platform is in motion (24), the vertical axis is used to collect and remove the measuring vessels (22) from the shield (20a),with simultaneous rotation of the exhaust manifold (22) operated by a rotating module (26).
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