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Cryogel bone scaffold based on chitosan and calcium phosphate bioceramics as well as method of producing it
Cryogel bone scaffold based on chitosan and calcium phosphate bioceramics as well as method of producing it
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机译：基于壳聚糖和磷酸钙生物陶瓷的低温凝胶骨支架及其生产方法
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摘要
The subject of the notification is macro-crusted chitosan-based skeletal scaffolding in a solution of acetic acid and phosphate-calcium biocerate, characterised by its presence as chitosan, agarose and phosphate-calcium biocerate in the form of powder or nanopowder, dispersed in 0,5 -3% aqueous solution of acetic acid, with: the weight ratios of the solid components corresponding to 0,5 -4% (w/v) chitosan,0,5 -5% (w/v) agarose and 1 -70% (w/v) phosphate calcium biocerate for acetic acid. The present notification also covers the production method of bone scaffolding, which consists of the subsequent use of two methods of introducing pores into a biomaterial using NaHCO3 as a source of CO2 (porogen) gas, andthe second lyophilisation process. Phosphate-calcium bioceramics in powder or nanopowder form and agarose are distributed in a solution of chitosan prepared in acetic acid. Sodium hydrocarbon (NaHCO3) is then added to the uniform mass as an intermediate source of CO2. The type of paste obtained was subjected to high temperatureand then freezing and the lyophilisation process. After lyophilisation, the biomaterial is immersed for ten minutes (sample volume 2 cm3) in 0,5 -2% (w/v) aqueous sodium solution to neutralise the residual acetic acid in the sample. After removing the biomaterial from the NaOH solution, rinse it three times for a 30-minute period in deionised water.
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