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Derivatives of tetrahydroimidazo (4,5-C) pyridine in the role of PD-L1 internationalization inductors

机译:四氢咪唑(4,5-C)吡啶的衍生物在PD-L1国际化电感器中的作用

摘要

Disclosed are compositions and methods for inducing the internalization of PD-L1. These methods include reducing the amount of PD-L1 on the cell surface by bringing the cell expressing PD-L1 into contact with a compound that binds to PD-L1 on the cell surface and induces the internalization of PD-L1. Compounds that induce the internalization of PD-L1 can be used to enhance, stimulate and / or increase the immune response and treat a disease or condition associated with PD-1.
机译:公开了诱导PD-L1内在化的组合物和方法。这些方法包括通过使表达PD-L1的细胞与与细胞表面上的PD-L1结合并诱导PD-L1内在化的化合物接触来减少细胞表面上PD-L1的量。诱导PD-L1内在化的化合物可用于增强,刺激和/或增加免疫应答,并治疗与PD-1相关的疾病或病症。

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