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HISTONE DEMETHYLASE INHIBITORS

机译：组蛋白去甲基化酶抑制剂

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摘要

The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

机译：本发明一般涉及用于治疗癌症和赘生性疾病的组合物和方法。本文提供了取代的氨基吡啶或酰胺基哒嗪衍生物化合物以及包含所述化合物的药物组合物。本发明的化合物和组合物可用于抑制组蛋白脱甲基酶。此外，本发明的化合物和组合物可用于治疗癌症，例如前列腺癌，乳腺癌，膀胱癌，肺癌和/或黑素瘤等。

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公开/公告号US2020172485A1

专利类型
公开/公告日2020-06-04

原文格式PDF
申请/专利权人 CELGENE QUANTICEL RESEARCH INC.;
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申请/专利号US202016782275
发明设计人 YOUNG K. CHEN;TOUFIKE KANOUNI;ZHE NIE;JEFFREY ALAN STAFFORD;JAMES MARVIN VEAL;MICHAEL BRENNAN WALLACE;
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申请日2020-02-05
分类号C07D213/79;C07D405/14;C07D213/81;C07D401/04;C07D409/14;C07D213/74;C07D237/24;C07D401/12;C07D405/12;C07D409/12;
国家 US
入库时间 2022-08-21 11:20:23

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