首页> 外国专利> COMPOSITIONS AND METHODS FOR IN VITRO ACTIVATION AND EXPANSION OF SERIAL KILLER T CELL POPULATIONS AND PASSIVE IMMUNIZATION OF A CANCER PATIENT WITH TUMOR CELL KILLING CELLS

COMPOSITIONS AND METHODS FOR IN VITRO ACTIVATION AND EXPANSION OF SERIAL KILLER T CELL POPULATIONS AND PASSIVE IMMUNIZATION OF A CANCER PATIENT WITH TUMOR CELL KILLING CELLS

机译：体外杀伤和杀灭肿瘤细胞杀伤性细胞的系列杀伤性T细胞群体和被动免疫的组合物和方法

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摘要

The described invention provides a method for in vitro immunoactivation of mononuclear cells by contact with one or more populations of engineered leukocyte stimulator cells genetically engineered to express a core of 3 essential immunomodulator peptides, and optionally additional R immunomodulator peptides, and use of a cell product comprising the expanded and activated mononuclear cell population comprising one or more subpopulations of cytotoxic serial killer cells for passive immunization of a cancer patient not currently under the influence of an immunosuppressive regimen.

机译：所描述的发明提供了一种通过与一个或多个基因工程改造以表达3种必需免疫调节肽和任选的其他R免疫调节肽的核心的工程化白细胞刺激细胞群体接触来体外免疫激活单核细胞的方法，以及细胞产品的用途包含扩增的和活化的单核细胞群，其包含一个或多个细胞毒性系列杀伤细胞亚群，用于被动免疫目前未受免疫抑制方案影响的癌症患者。

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公开/公告号US2020102538A1

专利类型
公开/公告日2020-04-02

原文格式PDF
申请/专利权人 ALLOPLEX BIOTHERAPEUTICS;
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申请/专利号US201916660442
发明设计人 FRANK BORRIELLO;
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申请日2019-10-22
分类号C12N5/0783;A61K35/17;A61K45/06;A61P35;C07K16/18;A61K39/395;C07K14/535;A61K38/19;C07K14/52;C07K14/705;A61K38/17;C07K14/525;
国家 US
入库时间 2022-08-21 11:20:35

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