首页> 外国专利> INACTIVATORS OF TOXOPLASMA GONDII ORNITHINE AMINOTRANSFERASE FOR TREATING TOXOPLASMOSIS AND MALARIA

INACTIVATORS OF TOXOPLASMA GONDII ORNITHINE AMINOTRANSFERASE FOR TREATING TOXOPLASMOSIS AND MALARIA

机译：弓形虫弓形虫氨酸转移酶的灭活剂治疗弓形虫病和疟疾

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摘要

Disclosed are methods, compounds, and compositions for treating infection by an Apicomplexan parasite that include administering a compound that selectively inactivates ornithine aminotransferase of the Apicomplexan parasite. Specifically, the methods, compounds, compounds may be utilized for treating infection by Toxoplasma gondii and toxoplasmosis and for treating infection by Plasmodium falciparum and malaria. The compounds disclosed herein are observed to selectively inactivate Toxoplasma gondii ornithine aminotransferase (TgOAT) relative to human OAT and relative to human γ-aminobutyric aminotransferase (GABA-AT).

机译：公开了用于治疗被蜂复合体寄生虫感染的方法，化合物和组合物，其包括施用选择性地使所述蜂复合体寄生虫的鸟氨酸氨基转移酶失活的化合物。具体地说，这些方法，化合物，化合物可用于治疗弓形虫和弓形虫感染以及恶性疟原虫和疟疾的感染。观察到本文公开的化合物相对于人OAT和相对于人γ-氨基丁酸氨基转移酶（GABA-AT）选择性地使弓形虫弓形鸟氨基转移酶（TgOAT）失活。

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公开/公告号US2020281880A1

专利类型
公开/公告日2020-09-10

原文格式PDF
申请/专利权人 NORTHWESTERN UNIVERSITY;
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申请/专利号US202016836870
发明设计人 RICHARD B. SILVERMAN;HOANG V. LE;RIMA L. MCLEOD;DUSTIN D. HAWKER;
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申请日2020-03-31
分类号A61K31/196;A61K31/13;A61K31/035;C12N9/10;A61K31/40;A61K31/341;A61K31/381;A61K31/03;C07C229/38;C07C229/34;
国家 US
入库时间 2022-08-21 11:21:00

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