首页> 外国专利> METHODS FOR IN VITRO INVESTIGATING MITOCHONDRIAL REPLICATION DYSFUNCTION IN A BIOLOGICAL SAMPLE, KITS AND USES THEREOF, THERAPEUTIC METHODS AGAINST PROGEROID-LIKE SYNDROMES OR SYMPTOMES AND SCREENING METHOD FOR IDENTIFYING PARTICULAR PROTEASE INHIBITOR(S) AND/OR NITROSO-REDOX STRESS SCAVENGER COMPOUND(S)

METHODS FOR IN VITRO INVESTIGATING MITOCHONDRIAL REPLICATION DYSFUNCTION IN A BIOLOGICAL SAMPLE, KITS AND USES THEREOF, THERAPEUTIC METHODS AGAINST PROGEROID-LIKE SYNDROMES OR SYMPTOMES AND SCREENING METHOD FOR IDENTIFYING PARTICULAR PROTEASE INHIBITOR(S) AND/OR NITROSO-REDOX STRESS SCAVENGER COMPOUND(S)

机译：生物样品中线粒体复制功能异常的检测方法，试剂盒及其用途，针对类脂状症状或症状的治疗方法以及用于识别特定病因和病原体的筛选方法

页面导航

摘要
著录项
相似文献

摘要

The invention relates to a method for in vitro investigating mitochondrial replication dysfunction in a biological sample removed from a subject susceptible of suffering from physiological ageing or physiopathological conditions related to physiological ageing, or physiopathological ageing or associated symptoms or conditions, in particular premature ageing or accelerated ageing, or of a progeroid syndrome, such as Cockayne syndrome (CS), or neurodegenerative disorders or symptoms thereof, in which the levels of at least one species selected in the group of: POLG1 protein, POLG1 RNA, POLG2 protein, protease(s) which have POLG as a target, in particular serine protease(s) such as HTRA3 protein, HTRA2 protein and, HTRA3 RNA or HTRA2 RNA, or any combination of these species, are investigated. The invention also relates to kits and uses thereof, therapeutic methods against progeroid-like syndromes or symptomes and screening method for identifying particular protease inhibitor(s) and/or nitroso-redox stress scavenger compound(s) having relevance for the symptoms discussed herein.

机译：本发明涉及一种方法的体外方法，该方法用于体外研究从易遭受患有生理老化或与生理老化有关的生理老化或生理病理状况或相关症状或状况，特别是过早老化或加速的疾病的受试者中取出的生物样品中的线粒体复制功能障碍。衰老，或诸如Cockayne综合征（CS）的早衰综合征或神经退行性疾病或其症状，其中选自以下组中的至少一种的水平：POLG1蛋白，POLG1 RNA，POLG2蛋白，蛋白酶研究了具有POLG作为靶标的），特别是丝氨酸蛋白酶，例如HTRA3蛋白，HTRA2蛋白和HTRA3 RNA或HTRA2 RNA，或这些种类的任何组合。本发明还涉及试剂盒及其用途，针对类胚状综合征或症状的治疗方法以及用于鉴定与本文讨论的症状相关的特定蛋白酶抑制剂和/或亚硝基-氧化还原应激清除剂化合物的筛选方法。

著录项

公开/公告号US2020049718A1

专利类型
公开/公告日2020-02-13

原文格式PDF
申请/专利权人 INSTITUT PASTEUR;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;
展开▼

申请/专利号US201916447890
发明设计人 LAURENT ARNAUD CHATRE;MIRIA RICCHETTI;ALAIN SARASIN;DENIS BIARD;
展开▼

申请日2019-06-20
分类号G01N33/68;C12Q1/6883;
国家 US
入库时间 2022-08-21 11:24:12

相似文献

专利
外文文献