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MOUSE MYOPIA-INDUCED MODEL AND ENDOPLASMIC RETICULUM STRESS SUPPRESSANT FOR PREVENTING AND SUPPRESSING MYOPIA

机译：小鼠近视眼诱发的模型和内镜网状应力抑制剂，用于预防和抑制近视眼

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摘要

A model that closely resembles human excessive myopia can be prepared by mounting a minus lens (2) and a protector (4) to a juvenile mouse, the minus lens having an angle and a width adjustable in response to growth of the mouse. Further, this model analysis shows that myopia induction causes endoplasmic reticulum stress in a sclera and the endoplasmic reticulum stress induces myopia. Furthermore, it is revealed that an endoplasmic reticulum stress suppressant, particularly, phenylbutyrate and tauroursodeoxycholic acid act as a myopia prevention/suppression agent.

机译：通过将负透镜（ 2 ）和保护器（ 4 ）安装到幼鼠上，可以制备出非常类似于人类过度近视的模型，负透镜具有一定角度宽度可根据鼠标的生长情况进行调整。此外，该模型分析表明，近视诱导在巩膜中引起内质网应激，而内质网应激引起近视。此外，揭示了内质网应激抑制剂，特别是苯基丁酸酯和牛磺去氧胆酸作为近视预防/抑制剂。 展开▼

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公开/公告号US2020150457A1

专利类型

公开/公告日2020-05-14

原文格式PDF

申请/专利权人 TSUBOTA LABORATORY INC.;
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申请/专利号US201916561776

发明设计人 SHINICHI IKEDA;XIAOYAN JIANG;KAZUO TSUBOTA;TOSHIHIDE KURIHARA;
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申请日2019-09-05

分类号G02C7/06;A01K67/02;A61K31/575;A61K9;

国家 US

入库时间 2022-08-21 11:25:09

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3. MURINE MYOPIA INDUCTION MODEL AND ENDOPLASMIC RETICULUM STRESS INHIBITOR FOR PREVENTING OR SUPPRESSING MYOPIA [P] . 欧洲知识产权局专利： EP3593817A1 . 2020-01-15

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4. MURINE MYOPIA INDUCTION MODEL AND ENDOPLASMIC RETICULUM STRESS INHIBITOR FOR PREVENTING OR SUPPRESSING MYOPIA [P] . 世界知识产权组织专利： WO2018164113A1 . 2018-09-13

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