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MURINE MYOPIA INDUCTION MODEL AND ENDOPLASMIC RETICULUM STRESS INHIBITOR FOR PREVENTING OR SUPPRESSING MYOPIA
MURINE MYOPIA INDUCTION MODEL AND ENDOPLASMIC RETICULUM STRESS INHIBITOR FOR PREVENTING OR SUPPRESSING MYOPIA
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机译：预防或抑制近视眼的小鼠近视眼诱导模型和内质网应激抑制剂
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摘要
A model that closely resembles human excessive myopia can be prepared by mounting a minus lens (2) and a protector (4) to a juvenile mouse, the minus lens having an angle and a width adjustable in response to growth of the mouse. Further, this model analysis shows that myopia induction causes endoplasmic reticulum stress in a sclera and the endoplasmic reticulum stress induces myopia. Furthermore, it is revealed that an endoplasmic reticulum stress suppressant, particularly, phenylbutyrate and tauroursodeoxycholic acid act as a myopia prevention and suppression agent.
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