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Oxo-M and 4-PPBP induction of tenogenic differentiation of perivascular tendon stem cells

机译:Oxo-M和4-PPBP诱导血管周肌腱干细胞腱向分化

摘要

Provided herein are compositions including oxotremorine (e.g., oxotremorine methiodide or Oxo-M) and 4-PPBP (e.g., 4-PPBP maleate). Also provided are methods of treating a connective tissue defect in a subject with oxotremorine and 4-PPBP. In addition, provided are scaffolds and methods of making same that include multiple fibers that include Oxo-M, 4-PPBP, and optionally icariin or kartogenin.
机译:本文提供的组合物包括氧代苯丁胺(例如氧代苯丁胺甲硫醇或Oxo-M)和4-PPBP(例如4-PPBP马来酸酯)。还提供了用氧代苯甲酸和4-PPBP治疗受试者的结缔组织缺陷的方法。另外,提供了包括多根纤维的支架及其制造方法,所述多根纤维包括Oxo-M,4-PPBP,以及任选地二十碳素或生姜素。

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