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Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate

机译：定向少突胶质前体细胞分化为髓鞘细胞命运

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摘要

The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.

机译：本发明提供了用神经递质受体调节剂诱导少突胶质祖细胞分化为成熟的髓鞘细胞命运的方法。本发明还提供了通过施用所述神经递质受体调节剂来刺激有需要的受试者中增加的髓鞘形成的方法。还提供了使用神经递质受体调节剂治疗患有脱髓鞘疾病的受试者的方法。

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公开/公告号US10493080B2

专利类型
公开/公告日2019-12-03

原文格式PDF
申请/专利权人 THE SCRIPPS RESEARCH INSTITUTE;NOVARTIS AG;
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申请/专利号US201715418572
发明设计人 PETER SCHULTZ;LUKE LAIRSON;VISHAL DESHMUKH;COSTAS LYSSIOTIS;
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申请日2017-01-27
分类号A61K31/5415;A61K31/439;A61K31/138;A61K31/40;A61K31/135;A61K31/137;A61K38/21;A61K39/395;A61K31/216;A61K31/46;A61K31/495;
国家 US
入库时间 2022-08-21 11:26:15

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