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DIRECTED DIFFERENTIATION OF OLIGODENDROCYTE PRECURSOR CELLS TO MYELINATING CELL FATE

机译：少突胶质前体细胞定向分化为髓鞘命运

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摘要

To provide methods for inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent.SOLUTION: A therapeutically effective amount of a neurotransmitter receptor-modulating substance selected from a muscarinic receptor antagonist, dopamine receptor antagonist, a histamine receptor antagonist, a β adrenergic receptor modulator and an opioid receptor modulator is administered, thereby stimulating increased myelination of nerves in the subject.SELECTED DRAWING: Figure 10A

机译：提供一种通过神经递质受体调节剂诱导少突胶质祖细胞分化为成熟的髓鞘细胞命运的方法。解决方案：治疗有效量的神经递质受体调节物质，选自毒蕈碱受体拮抗剂，多巴胺受体拮抗剂，组胺受体拮抗剂，β-肾上腺素能受体调节剂和阿片样物质受体调节剂被施用，从而刺激受试者中神经的髓鞘增多。选择的附图：图10A

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公开/公告号JP2020040981A

专利类型
公开/公告日2020-03-19

原文格式PDF
申请/专利权人 SCRIPPS RESEARCH INST;NOVARTIS AG;
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申请/专利号JP20190211952
发明设计人 PETER SCHULTZ;LAIRSON LUKE;VISHAL DESHMUKH;LYSSIOTIS COSTAS;
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申请日2019-11-25
分类号A61K45;A61P25;A61P25/02;A61K45/06;A61P43;A61K31/46;A61K31/215;A61K31/40;A61K31/495;A61K31/5415;A61K31/404;A61K31/137;A61K38/21;A61K38/02;A61K31/136;A61K39/395;C07K14/565;C07K16/28;
国家 JP
入库时间 2022-08-21 11:37:33

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