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Human antibody against aggrecanase-type ADAMTS species for therapeutics of aggrecanase-related diseases
Human antibody against aggrecanase-type ADAMTS species for therapeutics of aggrecanase-related diseases
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机译:抗软骨聚集蛋白聚糖酶相关疾病的人源抗软骨聚集蛋白聚糖酶型ADAMTS物种的抗体
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摘要
The present invention provides an antibody that specifically binds to human aggrecanase, and inhibits enzymatic activity of the human aggrecanase. In one embodiment, aggrecanase is ADAMTS4. In one embodiment, the antibody recognizes a particular epitope in human ADAMTS4, and inhibits not only aggrecanase activity of human ADAMTS4 but also aggrecanase activity of human ADAMTS5. In addition, the present invention also provides use of said antibody in the prophylaxis or treatment of the progression of arthritis.
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