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Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines

机译：去除血源性病原体，毒素和炎性细胞因子的装置和方法

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摘要

The present invention is directed to an integrated system and a method for utilizing the system to detect and remove blood-borne factors of interest, such as pathogens and/or toxins and/or cytokines, from blood or serum (blood) by contacting the blood with a solid, essentially nonporous substrate which has been surface treated with molecules or chemical groups (the adsorbent media or media) having a binding affinity for the pathogens and/or toxins to be removed (the adsorbents). The invention can be used to remove virulence factors, e.g. toxins, that are released from various pathogens. In one aspect, the invention is for the treatment of sepsis and infection, such as infections associated with battle field trauma.

机译：本发明涉及一种集成系统和一种方法，利用该系统通过接触血液来从血液或血清（血液）中检测和去除感兴趣的血液传播因子，例如病原体和/或毒素和/或细胞因子。用固体的，基本上无孔的底物进行表面处理，该底物已经对要去除的病原体和/或毒素（吸附剂）具有结合亲和力的分子或化学基团（一种或多种吸附剂介质）进行了表面处理。本发明可用于去除毒力因子，例如。从各种病原体释放的毒素。一方面，本发明用于治疗败血症和感染，例如与战场创伤相关的感染。

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公开/公告号US10537280B2

专利类型
公开/公告日2020-01-21

原文格式PDF
申请/专利权人 EXTHERA MEDICAL CORPORATION;
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申请/专利号US201313966244
发明设计人 KEITH MCCREA;ROBERT S. WARD;GEORGE PITARRA JR.;
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申请日2013-08-13
分类号A61B5;A61B5/02;A61B5/0205;A61B5/1468;A61M1/16;A61B5/01;A61B5/145;
国家 US
入库时间 2022-08-21 11:28:16

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