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首页> 外国专利> Single domain VHH antibodies directed to norovirus GI.1 and GII.4 and their use

Single domain VHH antibodies directed to norovirus GI.1 and GII.4 and their use

机译：针对诺如病毒GI.1和GII.4的单域VHH抗体及其用途

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Isolated VHH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.
机译：公开了分离地与诺如病毒多肽结合的V H H单克隆抗体。在一些实施方案中，诺如病毒是基因组I诺如病毒或基因组II诺如病毒。在其他实施方案中，诺如病毒是诺沃克病毒或MD2004病毒。在一些实施方案中，单克隆抗体特异性结合VP1。还公开了包括所公开的抗体，编码这些抗体的核酸，包括该核酸的表达载体以及表达该核酸的分离的宿主细胞的组合物。本文公开的抗体和组合物可用于检测生物学样品中诺如病毒的存在或检测诺如病毒感染。还公开了治疗和/或预防NoV感染的方法。

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