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Selective release systems for tumor therapeutics and diagnostics and biosensors for tumor tissue
Selective release systems for tumor therapeutics and diagnostics and biosensors for tumor tissue
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机译：用于肿瘤治疗和诊断的选择性释放系统以及用于肿瘤组织的生物传感器
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摘要
The present invention relates generally to sensors for tumor tissue and local delivery systems for therapeutic / diagnostic agents for targeted tumor therapy and tumor diagnosis. More specifically, the present invention provides a cation-stabilized biopolymer gel, in particular, destabilizes the gel in the presence of tumor cells or tumor tissue, especially stimuli generated by lysyl oxidase (LOX), Alginate gels for use as carrier matrices for tumor therapeutics and / or tumor diagnostics, characterized by being able to release tumor diagnostics, and cation stabilized biopolymers incorporating tumor therapeutics or diagnostics It relates to a pharmaceutical composition comprising a gel and optionally a further reporter substance. A related aspect of the invention is the administration of a pharmaceutical composition according to the invention, released after gel destabilization as a result of contact with the tumor-specific product to be detected, optionally compared to a reference value. The presence and / or presence of a tumor-specific product in the patient's body, characterized in that the patient's physiological sample, for example, the patient's blood, urine, stool, is tested for the presence and / or amount of a reporter substance. Or an in vitro method for detecting the amount. [Selection diagram] None
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