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Microorganism for drug delivery for the treatment of gastrointestinal diseases expressing and secreting P8 protein and pharmaceutical composition containing the same for prevention or treatment of gastrointestinal diseases

机译：用于表达和分泌P8蛋白的治疗胃肠道疾病的微生物用药物以及包含该微生物的药物组合物，用于预防或治疗胃肠道疾病

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摘要

The present invention relates to a drug delivery microorganism capable of being transformed by a gene construct containing a therapeutically active peptide, being safely transmitted into the intestine by oral administration, and expressing and secreting the therapeutic peptide in the gastrointestinal tract, and a gastrointestinal tract disease containing the same. The present invention relates to a pharmaceutical composition for prevention or treatment, and the present invention is to develop a lactic acid bacterium drug delivery system that introduces a lactic acid bacterium-derived anticancer protein into a lactic acid bacterium expression and secretion system and overexpresses and secretes it. It is expected to be widely used in the medical field as a therapeutic agent for natural protein colorectal disease.

机译：本发明涉及一种药物传递微生物，其能够被含有治疗活性肽的基因构建体转化，通过口服给药安全地传递到肠中，并在胃肠道中表达和分泌该治疗性肽以及胃肠道疾病。包含相同。发明领域本发明涉及用于预防或治疗的药物组合物，并且本发明开发一种乳酸菌药物递送系统，其将乳酸菌来源的抗癌蛋白引入乳酸菌表达和分泌系统中并过表达和分泌。它。有望作为天然蛋白结直肠疾病的治疗剂在医学领域中广泛使用。

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公开/公告号JP2020505910A

专利类型
公开/公告日2020-02-27

原文格式PDF
申请/专利权人セルバイオテックカンパニーリミテッド;
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申请/专利号JP20190531214
发明设计人チョン;ミョンジュン;
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申请日2018-10-16
分类号C12N1/21;A61K38/16;A61P1;A61P1/04;A61P31/04;A61P35;A61K45;C12N15/31;A61K35/744;A61K35/745;A61K35/747;
国家 JP
入库时间 2022-08-21 11:34:41

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