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Predicting the course and outcome of unconscious coma and post-coma states (including vegetative state) using blood tests
Predicting the course and outcome of unconscious coma and post-coma states (including vegetative state) using blood tests
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机译:使用验血预测无意识昏迷和昏迷后状态(包括植物状态)的进程和结果
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摘要
The present invention relates to the field of diagnostics in emergency medicine, trauma, intensive care and surgery, and can be used in medical practice. In order to objectively assess a subject's brain status in an unconscious or coma state, assess damage to nerve tissue, and predict the progress of a patient's condition, the present invention provides a method for identifying GluR6 and / or GluR7 in body fluids. It is proposed to measure the level of antibodies against fragments of the KAR receptor. KAR peptide fragments and antibodies thereto show structural damage to the brain and are specifically present only in unconscious patients. In the present invention, the magnitude and kinetics of these changes in antibody levels are used to predict both the recovery of the subject's condition in favorable outcomes and the potential for prolonged vegetative status or fatal outcome. [Selection diagram] FIG.
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