首页> 外国专利> Generation of atrial and ventricular cardiomyocyte lineages from human pluripotent stem cells

Generation of atrial and ventricular cardiomyocyte lineages from human pluripotent stem cells

机译:从人多能干细胞产生心房和心室心肌细胞谱系

摘要

A method of producing a population of cardiomyocytes from pluripotent stem cells is disclosed. The population may be enriched for either atrial or ventricular cardiomyocytes, and the resulting ventricular population may be essentially free of pacemaker cells. The method comprises incubating pluripotent stem cells in a suitable medium containing a BMP component and an activin component, and the amount of activin may be varied to enrich cardiomyocytes, either atria or ventricles. Besides enriched populations, methods of using the same to treat patients in need of heart repair are disclosed. [Selection diagram] Fig. 15
机译:公开了一种由多能干细胞产生心肌细胞群的方法。可以富集心房或心室心肌细胞的群体,并且所得心室群体可以基本上不含起搏器细胞。该方法包括在含有BMP成分和激活素成分的合适培养基中孵育多能干细胞,并且激活素的量可以变化以富集心房或心室的心肌细胞。除了丰富的人群,还公开了使用其来治疗需要心脏修复的患者的方法。 [选择图]图15

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号