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METHOD FOR OBTAINING EPIGENETIC CELL INFORMATION, METHOD FOR DETERMINING CELL CHARACTERISTICS, METHOD FOR ASSESSING DRUG SENSITIVITY OR SELECTING DRUG OR IMMUNOTHERAPEUTIC AGENT VARIETY, DISEASE DIAGNOSIS METHOD, SELF-REPLICATING VECTOR, ASSAY KIT, AND ANALYSIS DEVICE
METHOD FOR OBTAINING EPIGENETIC CELL INFORMATION, METHOD FOR DETERMINING CELL CHARACTERISTICS, METHOD FOR ASSESSING DRUG SENSITIVITY OR SELECTING DRUG OR IMMUNOTHERAPEUTIC AGENT VARIETY, DISEASE DIAGNOSIS METHOD, SELF-REPLICATING VECTOR, ASSAY KIT, AND ANALYSIS DEVICE
According to an embodiment, a method of obtaining epigenetic information of a cell is provided. The method includes introducing a reporter nucleic acid construct in a nuclear of a subject cell, self-replication of the reporter nucleic acid construct, detecting the presence/absence of a signal produced in the subject cell and/or a size thereof, and obtaining epigenetic information of the subject cell based on the result obtained. The reporter nucleic acid construct is characterized by transcribing the state of modification in a specific sequence on the genome of the subject cell onto a corresponding sequence thereof by substitution of a functional group during the self-replication in the nuclear of the subject cell, and producing a detectable signal depending on the state of presence of the transcribed functional group.
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