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Fast method to analyse blood samples for the identification of hemoglobin variants using electron transfer dissociation
Fast method to analyse blood samples for the identification of hemoglobin variants using electron transfer dissociation
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机译:使用电子转移解离分析血液样本以鉴定血红蛋白变异体的快速方法
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摘要
A method of screening or testing a blood sample comprising ionising a native human haemoglobin sample to generate parent or precursor ions, subjecting the parent or precursor ions to electron transfer dissociation (ETD) fragmentation so as to generate a plurality of fragment ions, mass analysing the fragment ions and determining whether or not the fragment ions include fragment ions which are indicative of a variant of hemoglobin. The variant may comprise the sickle heterozygote (HbS, HbAS).
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