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EDARAVON COMBINATION FOR TREATING ISCHEMIC BRAIN INJURY

机译：依达拉奉联合治疗缺血性脑损伤

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FIELD: medicine; pharmaceuticals.;SUBSTANCE: invention refers to pharmaceutical industry, namely to a composition/combination with antioxidant activity for treating a cerebrum disease specified in acute cerebrovascular accident (ACE), amyotrophic lateral sclerosis (ALS), transient ischemic attack (TIA) in an acute period and after a previous attack, chronic cerebral ischemia, cognitive and behavioral disorders in vascular cerebral diseases or neurodegenerative diseases. Combination with antioxidant activity for treating a cerebrum disease selected from acute cerebral circulation disorder (AMCD), amyotrophic lateral sclerosis (ALS), transient ischemic attack (TIA) in an acute period and after a previous attack, chronic cerebral ischemia, cognitive and behavioral disorders in vascular cerebral diseases or neurodegenerative diseases, wherein said combination contains effective amounts of (a) edaravon and (b) at least one substance selected from the group consisting of ebselen, resveratrol, uric acid, dehydroascorbic acid and disufen ton, and the active substances are in daily dosages: edaravon 30–700 mg/day; ebselen 200–3,600 mg / day; resveratrol 2–5,000 mg/day; uric acid 250–2,000 mg/day; dehydroascorbic acid 7,000–35,000 mg/day; sodium disufenton 500–6,000 mg/day. Pharmaceutical composition with antioxidant activity for treating a brain disease selected from AMCD, ALS, TIA in acute period and after suffered attack, chronic cerebral ischemia, cognitive and behavioral disorders in cerebral vascular diseases or neurodegenerative diseases. Kit with antioxidant activity for treating a brain disease selected from AMCD, ALS, TIA in acute period and after suffered attack, chronic cerebral ischemia, cognitive and behavioral disorders in cerebral vascular diseases or neurodegenerative diseases. Using the combination with antioxidant activity for treating a brain disease selected from AMCD, ALS, TIA in acute period and after suffered attack, chronic cerebral ischemia, cognitive and behavioral disorders in cerebral vascular diseases or neurodegenerative diseases. Use of the composition with antioxidant activity for treating a brain disease selected from AMCD, ALS, TIA in an acute period and after a previous attack, chronic cerebral ischemia, cognitive and behavioral disorders in cerebral vascular diseases or neurodegenerative diseases. Use of a kit with antioxidant activity for treating a brain disease selected from AMCD, ALS, TIA in acute period and after a previous attack, chronic cerebral ischemia, cognitive and behavioral disorders in cerebral vascular diseases or neurodegenerative diseases. Method for treating a brain disease selected from AMCD, ALS, TIA in acute period and after a previous attack, chronic cerebral ischemia, cognitive and behavioral disorders in cerebral vascular diseases or neurodegenerative diseases, in which the neuroprotective preparations are used in effective amounts of a combination, composition or kit.;EFFECT: above described combination or kit or composition have a synergetic antioxidant effect, are effective for treating a brain disease selected from AMCD, ALS, TIA in acute period and after suffered attack, chronic cerebral ischemia, cognitive and behavioral disorders in cerebral vascular diseases or neurodegenerative diseases.;24 cl, 16 tbl, 3 ex
机译：领域：医学;药物：本发明涉及制药工业，即具有抗氧化活性的组合物/组合物，用于治疗急性脑血管意外（ACE），肌萎缩性侧索硬化（ALS），短暂性脑缺血发作（TIA）中指定的大脑疾病在先前发作期间和之后，出现慢性脑缺血，血管性脑病或神经退行性疾病的认知和行为障碍。结合抗氧化活性可治疗急性期和先前发作后选自急性脑循环障碍（AMCD），肌萎缩性侧索硬化症（ALS），短暂性脑缺血发作（TIA）的大脑疾病，慢性脑缺血，认知和行为障碍在血管性脑疾病或神经退行性疾病中，其中所述组合包含有效量的（a）依达拉奉和（b）至少一种选自依布硒啉，白藜芦醇，尿酸，脱氢抗坏血酸和二氟尿嘧啶的物质，以及活性物质每日剂量：edaravon 30–700 mg /天;依布硒仑200–3,600毫克/天;白藜芦醇2–5,000 mg /天;尿酸250–2,000毫克/天;脱氢抗坏血酸7,000–35,000 mg /天;舒芬妥钠钠500–6,000毫克/天。具有抗氧化活性的药物组合物，用于治疗急性期和发作后选自AMCD，ALS，TIA的脑部疾病，慢性脑缺血，脑血管疾病或神经退行性疾病中的认知和行为障碍。具有抗氧化活性的试剂盒，用于治疗急性期和发作后选自AMCD，ALS，TIA的脑部疾病，慢性脑缺血，脑血管疾病或神经退行性疾病的认知和行为障碍。将具有抗氧化活性的组合物用于治疗急性期和发作后选自AMCD，ALS，TIA的脑部疾病，慢性脑缺血，脑血管疾病或神经退行性疾病的认知和行为障碍。具有抗氧化活性的组合物在急性期和先前发作后用于治疗选自AMCD，ALS，TIA的脑部疾病，慢性脑缺血，脑血管疾病或神经退行性疾病中的认知和行为障碍的用途。具有抗氧化活性的试剂盒在急性期和先前发作后用于治疗选自AMCD，ALS，TIA的脑部疾病，慢性脑缺血，脑血管疾病或神经退行性疾病中的认知和行为障碍的用途。在急性期和先前发作后治疗选自AMCD，ALS，TIA的脑部疾病，慢性脑缺血，脑血管疾病或神经退行性疾病中的认知和行为失常的方法，其中神经保护制剂的有效量为效果：上述组合或试剂盒或组合物具有协同抗氧化作用，可在急性期和发作后有效治疗选自AMCD，ALS，TIA的脑部疾病，慢性脑缺血，认知障碍和认知障碍。脑血管疾病或神经退行性疾病中的行为障碍。; 24 cl，16 tbl，3 ex

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