首页> 外国专利> RECOMBINANT STREPTOCOCCUS PYOGENES (pT7ErmEMM) STRAIN - TUMOR GROWTH INHIBITOR

RECOMBINANT STREPTOCOCCUS PYOGENES (pT7ErmEMM) STRAIN - TUMOR GROWTH INHIBITOR

机译：重组链球菌脓杆菌（pT7ErmEMM）菌株-肿瘤生长抑制剂

页面导航

摘要
著录项
相似文献

摘要

FIELD: biotechnology.;SUBSTANCE: invention relates to the field of biotechnology. Disclosed is a recombinant strain of bacteria Streptococcus pyogenes M39 "Gurov", obtained by transforming the Streptococcus pyogenes "Gurov" strain with plasmid pT7ErmEMM, obtained based on the vector p7ermB by embedding on the HindIII and EcoRI sites of the emm gene fragment. Disclosed recombinant strain exhibits marked anti-tumor activity towards hepatoma and sarcoma tumors.;EFFECT: invention increases anti-tumor activity, reduces pathogenicity and improves survival rate of recombinant strain Streptococcus pyogenes and can be used in therapy of malignant growths.;1 cl, 3 dwg

机译：技术领域本发明涉及生物技术领域。本发明公开了一种细菌化脓性链球菌M39“ Gurov”的重组菌株，该重组菌株通过用质粒pT7ErmEMM转化化脓性链球菌“ Gurov”菌株而获得，该质粒基于载体p7ermB，通过嵌入在emm基因片段的HindIII和EcoRI位点上而获得。公开的重组菌株对肝癌和肉瘤肿瘤表现出显着的抗肿瘤活性。效果：本发明增加了重组菌株化脓性链球菌的抗肿瘤活性，降低了致病性并提高了存活率，可用于治疗恶性肿瘤。1cl， 3 dwg

著录项

公开/公告号RU2685947C2

专利类型
公开/公告日2019-04-23

原文格式PDF
申请/专利权人 SUVOROV ALEKSANDR NIKOLAEVICH;
展开▼

申请/专利号RU20160152829
发明设计人 SUVOROV ALEKSANDR NIKOLAEVICH (RU);CHERESHNEV VALERIJ ALEKSANDROVICH (RU);SUVOROVA MARIYA ALEKSANDROVNA (RU);DUPLIK NADEZHDA VLADLENOVNA (RU);KISELEVA EKATERINA PROKHOROVNA (RU);GRYAZNOVA DIANA VASILEVNA (RU);TSAPIEVA ANNA NIKOLAEVNA (RU);
展开▼

申请日2016-12-30
分类号C12N1/21;
国家 RU
入库时间 2022-08-21 11:46:17

相似文献

专利
外文文献
中文文献