首页> 外国专利> NUCLEOTIDE SEQUENCE ENCODING THE DBPAG POLYPEPTIDE, ADVANTAGEOUS FOR SERODIAGNOSIS OF LYME BORRELIOSIS, PETDBPAGNH RECOMBINANT PLASMID DNA, ENCODING DBPAG COMBINED POLYPEPTIDE, RECOMBINANT BACTERIA STRAIN ESCHERICHIA COLI BL21(DE3)/PETDBPAGNH - PRODUCER OF DBPAG POLYPEPTIDE, DBPAG POLYPEPTIDE AND METHOD FOR PREPARATION THEREOF

NUCLEOTIDE SEQUENCE ENCODING THE DBPAG POLYPEPTIDE, ADVANTAGEOUS FOR SERODIAGNOSIS OF LYME BORRELIOSIS, PETDBPAGNH RECOMBINANT PLASMID DNA, ENCODING DBPAG COMBINED POLYPEPTIDE, RECOMBINANT BACTERIA STRAIN ESCHERICHIA COLI BL21(DE3)/PETDBPAGNH - PRODUCER OF DBPAG POLYPEPTIDE, DBPAG POLYPEPTIDE AND METHOD FOR PREPARATION THEREOF

机译：编码DBPAG多肽的核苷酸序列，对溶血性梅毒的血清学诊断有优势，PETDBPAGNH重组质粒DNA，编码DBPAG结合多肽，重组细菌菌株大肠埃希伯氏菌多巴菌素多肽（DE3）的DB23 / DEPA

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FIELD: biotechnology.;SUBSTANCE: invention relates to the field of biotechnology, specifically to the production of an immunogenic polypeptide that provides for the formation of an immune response against infection caused by spirochetes of the Borrelia burgdorferi sensu lato complex, and can be used for serodiagnosis of tick-borne borreliosis. Recombinantly, in cells of the E. coli BL21 (DE3)/pETdbpagNH strain of bacteria, a DBPAG fusion polypeptide consisting of the immunogenic domains of the Borrelia garinii and Borrelia afzelii DBPA proteins is obtained.;EFFECT: invention provides a new polypeptide that is advantageous for the development of a new test system for the diagnosis of Lyme borreliosis.;5 cl, 5 dwg, 2 tbl, 5 ex

机译：免疫原性多肽的制备技术领域本发明涉及生物技术领域，尤其涉及提供免疫原性多肽的制备，所述免疫原性多肽提供针对由疏螺旋体（Borrelia burgdorferi sensu lato）复合体的螺旋体引起的感染的免疫应答的形成，并且可以用于tick传性贝氏杆菌病的血清学诊断。重组地，在大肠杆菌BL21（DE3）/ pETdbpagNH菌株的细胞中，获得了由鲍氏疏螺旋体和非洲疏螺旋体的DBPA蛋白的免疫原性结构域组成的DBPAG融合多肽。有利于开发新的诊断莱姆病的测试系统。; 5 cl，5 dwg，2 tbl，5 ex

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公开/公告号RU2681229C1

专利类型
公开/公告日2019-03-05

原文格式PDF
申请/专利权人 FEDERALNOE BYUDZHETNOE UCHREZHDENIE NAUKI GOSUDARSTVENNYJ NAUCHNYJ TSENTR PRIKLADNOJ MIKROBIOLOGII I BIOTEKHNOLOGII (FBUN GNTS PMB);
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申请/专利号RU20170138441
发明设计人 PANFERTSEV EVGENIJ ALEKSANDROVICH (RU);BARANOVA EVGENIYA VLADIMIROVNA (RU);MOCHALOV VLADIMIR VYACHESLAVOVICH (RU);BIKETOV SERGEJ FEDOROVICH (RU);SOLOVEV PAVEL VLADIMIROVICH (RU);GORBATOV ALEKSEJ ALEKSANDROVICH (RU);
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申请日2017-11-03
分类号C07K19;C07K14/20;C12N15/31;C12N15/63;G01N33/569;
国家 RU
入库时间 2022-08-21 11:46:19

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