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METHOD FOR ASSESSING THE REGIONAL SPREAD OF BREAST CANCER BY SINGLE-PHOTON EMISSION COMPUTER TOMOGRAPHY

机译:单光子发射计算机断层摄影术评估乳腺癌区域扩散的方法

摘要

FIELD: medicine.;SUBSTANCE: invention relates to medicine, namely to oncology and radiation diagnostics, and can be used to assess the regional prevalence of breast cancer using single-photon emission computed tomography. Radiopharmaceutical is made just before its intravenous administration. To do this, 4 ml of sodium pertechnetate Na99mTcO4 is injected under aseptic conditions with a syringe from the generator to the reagent vial. Composition of the reagent is as follows: 1-thio-D-glucose sodium salt hydrate - 0.625 mg, tin 2-water dichloride - 0.044–0.052 mg, ascorbic acid - not more than 0.125 mg, sodium chloride 8.0–10.0 mg, water for injection - up to 1 ml. Contents of the vial is mixed by shaking and incubated at room temperature for 30 minutes until complete dissolution of the reagent. Resulting radiopharmaceutical is injected on the basis of technetium-99m labelled derivative of glucose at a dose of 500 MBq. 40 minutes after radiopharmaceutical injection, single-photon emission computed tomography is performed on a two-detector gamma camera. Resulting images are post-processed. Metastatic lesion of regional lymph nodes is diagnosed when imaging radiotherapy sites of radiopharmaceuticals in axillary regions.;EFFECT: method provides improved accuracy and informative assessment of regional prevalence of breast cancer through the use of radiopharmaceuticals based on technetium-99m labelled derived of glucose and single-photon emission computed tomography.;1 cl, 1 dwg, 1 tbl, 1 ex
机译:技术领域本发明涉及医学,即肿瘤学和放射诊断学,并且可以用于使用单光子发射计算机断层摄影术来评估乳腺癌的局部患病率。放射性药物是在静脉给药之前制造的。为此,在无菌条件下用注射器将4 ml高99酸钠Na 99m TcO 4 从发生器注入试剂瓶中。该试剂的组成如下:1-硫代-D-葡萄糖钠水合物-0.625 mg,二氯化锡-二氯化锡-0.044-0.052 mg,抗坏血酸-不超过0.125 mg,氯化钠8.0-10.0 mg,水注射-最多1毫升。摇动混合小瓶的内容物,并在室温下孵育30分钟,直到试剂完全溶解。根据of- 99m标记的葡萄糖衍生物以500 MBq的剂量注射所得的放射性药物。放射性药物注射后40分钟,在两探测器伽马相机上进行单光子发射计算机断层扫描。生成的图像将进行后处理。对腋窝区域放射性药物的放射治疗部位进行成像时,可诊断出局部淋巴结转移灶。效果:该方法通过使用基于tech和葡萄糖标记的99m标记的放射性药物,提高了乳腺癌区域患病率的准确性和信息量-光子发射计算机断层扫描; 1 cl,1 dwg,1 tbl,1 ex

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