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首页> 外国专利> MODEL OF CLOSED BLUNT SEVERE LIVER INJURY WITH COAGULOPATHY IN SMALL LABORATORY ANIMALS

MODEL OF CLOSED BLUNT SEVERE LIVER INJURY WITH COAGULOPATHY IN SMALL LABORATORY ANIMALS

机译：小实验室动物闭合性伴有血凝性的严重肝损伤模型

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FIELD: medicine.;SUBSTANCE: invention relates to medicine, namely to experimental surgery. Use the device for the injury of small laboratory animals by the "blow" mechanism, namely the traumatic impact of a cargo weighing 425 g, which falls from a height of 28 cm and transfers its energy to the anterior abdominal wall of a laboratory rat weighing 360–390 g, lying in a supine position with the orientation of the center of the shock pad with a diameter of 3.5 cm 5 mm to the right and above the tip of the xiphoid process. 1 ml of blood is taken from the carotid artery immediately before the injury and 60 minutes after it for 1 minute, which simulates excessive bleeding from the liver vessels immediately after the injury and its amplification during laparotomy, when a revision of the abdominal cavity is performed. Necessity of such sampling is dictated by the faster formation of fibrin in rats and, as a consequence, an earlier stop of bleeding compared with a human, even with massive liver damage. First 20 minutes after the injury simulate the situation of waiting for medical care to the victims, so there is no fluid resuscitation, which corrects hypotension. Prehospital phase is modeled from 20 to 60 minutes, when the patient receives infusion therapy with maintaining systolic blood pressure at the level of 80–90 mm Hg and is delivered to the hospital. By the 60th minute, a laparotomy is performed, and one or another surgical technique is performed. Study of the hemostasis system showed the presence of coagulopathy after such an injury by 60th minute.;EFFECT: method allows to create a model of a closed blunt severe liver injury with coagulopathy in small laboratory animals, which is closest to the real situation in life.;1 cl, 1 ex
机译：技术领域本发明涉及医学，即实验外科。使用该装置通过“吹气”机制对小型实验动物造成伤害，即重达425 g的货物的撞击力从28厘米的高度坠落，并将其能量传递至称重的实验鼠的腹壁360-390 g，仰卧位，剑突中心位于右侧和剑突顶部上方，直径为3.5 cm 5 mm。刚受伤前及其后60分钟从颈动脉中抽取1毫升血液，这模拟了刚受伤后立即从肝血管中大量出血，并在剖腹手术时放大了腹腔，这会导致腹腔翻修。这种采样的必要性是由大鼠中血纤蛋白形成更快，因此与人类相比出血停止得更早，即使肝脏受到严重损害也是如此。受伤后的前20分钟模拟了对受害者的等待医疗情况，因此没有进行液体复苏，可以纠正低血压。当患者接受输注治疗并将收缩压维持在80-90 mmHg的水平时，将住院前阶段建模为20至60分钟，然后将其送往医院。在第60分钟之前，进行剖腹手术，并执行一项或多项外科手术技术。对止血系统的研究表明，这种损伤在60分钟后出现了凝血病。效果：该方法可以在小型实验动物中建立一种闭合性钝性严重肝损伤伴凝血病的模型， ; 1 cl，1 ex

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