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首页> 外国专利> luteolin-7-O-diglucuronide apigenin-7-O-diglucuronide PHARMACEUTICAL COMPOSITION COMPRISING LUTEOLIN-7-O-DIGLUCURONIDE APIGENIN-7-O-DIGLUCURONID ISOLATED FROM PERILLA FRUTESCENS VAR. ACUTA LEAF EXTRACT FOR IMPROVING OCULAR FATIGUE

luteolin-7-O-diglucuronide apigenin-7-O-diglucuronide PHARMACEUTICAL COMPOSITION COMPRISING LUTEOLIN-7-O-DIGLUCURONIDE APIGENIN-7-O-DIGLUCURONID ISOLATED FROM PERILLA FRUTESCENS VAR. ACUTA LEAF EXTRACT FOR IMPROVING OCULAR FATIGUE

机译：木犀草素-7-O-二葡糖醛酸芹菜素-7-O-二葡糖醛酸苷组成的药用组合物，是由芦苇-7-O-二葡糖醛酸APIGENIN-7-O-二葡糖醛酸分离自紫苏果。 ACUTA叶提取物可改善眼疲劳

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摘要

The present invention relates to a health functional food for preventing and ameliorating eye fatigue, comprising luteolin-7-o-diglucuronide and apigenin-7-o-diglucuronide compounds isolated from an extract of Perilla frutescens Britton var. leaves. It is determined that active ingredients of a freeze-dried material and a spray-dried material of Perilla frutescens Britton var. leaves of the present invention contain the equal amounts of luteolin-7-O-diglucuronide and apigenin-7-O-diglucuronide compounds. Contents of NO and cGMP related to eye relaxation are increased and a content of [Ca^2+] i-ions is decreased in ciliary muscle cells (rCSMCs) isolated from rat eyes. In addition, through animal testing, a content of cGMP is increased. These compounds increase the content of cGMP in ciliary muscle cells isolated from rat eyes, thereby being usable in a composition for a health functional food for preventing and ameliorating eye fatigue.
机译：本发明涉及一种用于预防和改善眼睛疲劳的保健功能食品，其包含从紫苏紫苏提取物中提取的木犀草素-7-邻-二葡糖醛酸和芹菜素-7-邻-二葡糖醛酸化合物。树叶。确定了紫苏的冷冻干燥材料和喷雾干燥材料的活性成分。本发明的叶子含有等量的木犀草素-7-O-二葡糖醛酸苷和芹菜素-7-O-二葡糖醛酸苷化合物。从大鼠眼中分离出的睫状肌细胞（rCSMCs）中与眼睛松弛有关的NO和cGMP含量增加，[Ca ^ 2 +] i离子含量降低。另外，通过动物试验，cGMP的含量增加。这些化合物增加了从大鼠眼睛分离的睫状肌细胞中cGMP的含量，从而可用于用于预防和减轻眼睛疲劳的保健功能食品的组合物中。

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