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USE OF ANTI-HUMAN SIRPA V1 ANTIBODIES AND METHOD FOR PRODUCING ANTI-SIRPA V1 ANTIBODIES

机译：抗人SIRPA V1抗体的使用和生产抗SIRPA V1抗体的方法

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摘要

The invention is in the field of immunotherapy. The present invention provides antibodies useful in therapeutic and diagnostic applications targeting human SIRPa, said antibodies enhancing the cross-presentation of antigens to T cells. The invention also provides antibodies against specific isoforms of SIRP a and able to disrupt the interaction between those isoforms of SIRP a and human CD47 for use in treating or preventing a disease, or diagnostic applications, and methods for producing and/or selecting anti-human SIRPa antibodies that bind with different affinities to various isoforms of human SIRP members.

机译：本发明属于免疫疗法领域。本发明提供了可用于靶向人SIRPA的治疗和诊断应用的抗体，所述抗体增强了抗原向T细胞的交叉呈递。本发明还提供了针对SIRP a的特异性同工型的抗体，该抗体能够破坏SIRP a的那些同工型与人CD47之间的相互作用，用于治疗或预防疾病或诊断应用，以及产生和/或选择抗人的方法。 SIRPa抗体以不同的亲和力与人SIRP成员的各种同工型结合。

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公开/公告号WO2019175218A1

专利类型
公开/公告日2019-09-19

原文格式PDF
申请/专利权人 OSE IMMUNOTHERAPEUTICS;
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申请/专利号WO2019EP56250
发明设计人 POIRIER NICOLAS;GAUTTIER VANESSA;MARY CAROLINE;PENGAM SABRINA;VANHOVE BERNARD;
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申请日2019-03-13
分类号C07K16/28;C07K14/705;A61K39;
国家 WO
入库时间 2022-08-21 11:53:14

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