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A METHOD FOR ENANTIOSELECTIVE CARBENE C-H INSERTION USING AN IRON-CONTAINING PROTEIN CATALYST

机译：一种含铁蛋白催化剂的对映选择性碳C-H插入方法

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摘要

Methods for catalyzing C-H insertion reactions using heme enzymes are described. The present disclosure provides a method for producing a C-H insertion product comprising providing an substrate having an sp³-hybridized C-H bond, a carbene precursor such as a diazo reagent, and a heme enzyme, and admixing the components in a reaction for a time sufficient to produce the C-H insertion product. Heme enzyme variants useful for carrying out in vivo and in vitro C-H insertion reactions, as well as expression vectors and host cells expressing the heme enzymes, are also described.

机译：描述了使用血红素酶催化C-H插入反应的方法。本公开提供了一种用于制备CH插入产物的方法，该方法包括提供具有sp ^{3 杂化的CH键，卡宾前体例如重氮试剂和血红素酶的底物，并将这些组分混合在反应中足以产生CH插入产物的时间。还描述了可用于进行体内和体外 C-H插入反应的血红素酶变体，以及表达该血红素酶的表达载体和宿主细胞。} 展开▼

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公开/公告号WO2019147865A1

专利类型

公开/公告日2019-08-01

原文格式PDF

申请/专利权人 ZHANG RUIJIE;WOHLSCHLAGER LENA;RENATA HANS;ARNOLD FRANCES H.;CHEN KAI;CALIFORNIA INSTITUTE OF TECHNOLOGY;
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申请/专利号WO2019US15027

发明设计人 ZHANG RUIJIE;WOHLSCHLAGER LENA;RENATA HANS;ARNOLD FRANCES H.;CHEN KAI;
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申请日2019-01-24

分类号C12P17/18;

国家 WO

入库时间 2022-08-21 11:53:46

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