EUKARYOTIC INITIATION FACTOR 4 RECRUITING APTAMERS FOR ENHANCING TRANSLATION
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机译:真核起始因子4招聘用于增强翻译的适位
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摘要
The present invention relates to ribonucleic acids containing an open reading frame (ORF) and one or more aptamer sequence(s) specific for a component of eukaryotic initiation factor 4 F (elF4F) complex, which aptamer sequence binds to elF4F complex but does not inhibit translation. The invention further relates to DNA molecules such as vectors coding for the RNA. It also relates to vectors containing an elF4F complex aptamer sequence ready for insertion of a recombinant gene. Furthermore, the invention relates to methods for expression of recombinant genes employing said RNA or DNA molecules.
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