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Diagnostic prediction of rheumatoid arthritis and systemic lupus erythematosus

机译：类风湿关节炎和系统性红斑狼疮的诊断预测

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摘要

Method of determining in a sample of a subject the presence of two or more antibodies comprising: - contacting said sample with: i. a citrullinated hnRNP-D (hnRNP-DL) -like polypeptide comprising the sequence of SEQ ID NO: and ii. at least one other hnRNP polypeptide that is not sequence homologous to said hnRNPDL polypeptide, wherein said other hnRNP polypeptide has a sequence selected from the group consisting of SEQ ID NOs: 6 to 17, and / or a cyclic citrullinated peptide (CCP) and / or a polypeptide comprising at least the Fc part of IgG, and - determining whether an antibody is present in said sample that specifically recognizes said citrulinated hnRNP-DL polypeptide and further determining whether at least one additional antibody is present in said sample that specifically recognizes said at least one other hnRNP polypeptide that is not sequence homologue to said hnRNP-DL polypeptide, and / or said CCP and / or a polypeptide comprising at least the Fc part of IgG, respectively.

机译：确定受试者样品中两种或更多种抗体的存在的方法，包括：-使所述样品与：i。包含SEQ ID NO：和ii的序列的瓜氨酸化的hnRNP-D（hnRNP-DL）样多肽。至少一个与所述hnRNPDL多肽不同源的其他hnRNP多肽，其中所述另一个hnRNP多肽具有选自SEQ ID NO：6至17和/或环状瓜氨酸化肽（CCP）的序列和/或至少包含IgG的Fc部分的多肽，以及-确定所述样品中是否存在特异性识别所述瓜氨酸化的hnRNP-DL多肽的抗体，并进一步确定所述样品中是否存在至少一种特异性识别所述瓜分的抗体与所述hnRNP-DL多肽和/或所述CCP和/或至少分别包含IgG的Fc部分的序列不同源的至少一种其他hnRNP多肽。

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公开/公告号ES2703999T3

专利类型
公开/公告日2019-03-13

原文格式PDF
申请/专利权人 MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.;CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN;
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申请/专利号ES20090796375T
发明设计人 KONTHUR ZOLTÁN;LEHRACH HANS;SKRINER KARL;
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申请日2009-12-18
分类号G01N33/564;C07K16/44;G01N33/68;
国家 ES
入库时间 2022-08-21 11:59:28

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